Chen Senzhen, Chen Jinfeng, Zheng Shujing, Yan Yiling, Huang Mengting, Chen Nuoqi
Zhangzhou Affiliated Hospital of Fujian Medical University, The Second Department of Endocrinology and Metabolism, Zhangzhou, Fujian, China.
Zhangzhou Affiliated Hospital of Fujian Medical University, Department of Pathology, Zhangzhou, Fujian, China.
Front Endocrinol (Lausanne). 2025 Jun 9;16:1541388. doi: 10.3389/fendo.2025.1541388. eCollection 2025.
To investigate the correlation between serum 25-hydroxyvitamin D (25[OH]D) levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) and to evaluate its predictive value for DPN.
Participants were divided into three groups based on 25(OH)D levels: deficient, insufficient, and normal. The relationship between 25(OH)D and DPN, as well as the correlation of 25(OH)D and DPN with various indicators, was analyzed.
Compared to the non-DPN group (NDPN), the DPN group had significantly lower levels of 25(OH)D3 (22.10 ± 0.77 vs. 24.45 ± 0.66 ng/mL) and total 25(OH)D (23.12 ± 0.74 vs. 25.68 ± 0.67 ng/mL). In addition, significant differences were observed in body mass index (BMI), resting heart rate (RHR), triglyceride (TG), free triiodothyronine (FT3), and blood urea nitrogen (BUN) between the two groups ( < 0.05). Multivariate analysis identified 25(OH)D3, total 25(OH)D, FT3, BMI, and RHR as risk factors for DPN. The receiver operating characteristic (ROC) curve analysis revealed that the optimal cutoff value for 25(OH)D3 in predicting DPN in T2DM was 18.85 ng/mL [area under the curve (AUC) 0.76, 95% confidence interval (CI): 0.697-8.823], while the optimal cutoff for total 25(OH)D was 19.94 ng/mL (AUC 0.765, 95% CI: 0.703-0.828).
Serum 25(OH)D levels can serve as a simple and effective screening tool to predict the occurrence of DPN in patients with T2DM.
探讨2型糖尿病（T2DM）患者血清25-羟维生素D（25[OH]D）水平与糖尿病周围神经病变（DPN）的相关性，并评估其对DPN的预测价值。
根据25(OH)D水平将参与者分为三组：缺乏组、不足组和正常组。分析25(OH)D与DPN之间的关系，以及25(OH)D和DPN与各项指标的相关性。
与非DPN组（NDPN）相比，DPN组的25(OH)D3水平（22.10±0.77对24.45±0.66 ng/mL）和总25(OH)D水平（23.12±0.74对25.68±0.67 ng/mL）显著更低。此外，两组在体重指数（BMI）、静息心率（RHR）、甘油三酯（TG）、游离三碘甲状腺原氨酸（FT3）和血尿素氮（BUN）方面存在显著差异（<0.05）。多因素分析确定25(OH)D3、总25(OH)D、FT3、BMI和RHR为DPN的危险因素。受试者工作特征（ROC）曲线分析显示，25(OH)D3预测T2DM患者DPN的最佳截断值为18.85 ng/mL [曲线下面积（AUC）0.76，95%置信区间（CI）：0.697 - 8.823]，而总25(OH)D的最佳截断值为19.94 ng/mL（AUC 0.765，95% CI：0.703 - 0.828）。
血清25(OH)D水平可作为预测T2DM患者DPN发生的简单有效筛查工具。
