Mohanrao Raja, Pinto Clyde S, Suchenko Andrejus, Clarkson Guy J, Wills Martin, Roesner Stefan, Shipman Michael, Balasubramanian Mohan K
Centre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.
Department of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, UK.
ChemistrySelect. 2025 Feb 27;10(9). doi: 10.1002/slct.202405738. eCollection 2025 Mar.
A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced electron delocalization between donor and acceptor groups compared to those with a dihydro[1,4]thiazine skeleton. These easily synthesized clickable fluorophores were successfully applied in both in vitro and in vivo bioimaging following protein conjugation.
报道了一系列由四氟对苯二甲腈衍生的小型化、可点击的单苯基金属荧光团。与具有二氢[1,4]噻嗪骨架的荧光团相比，基于四氢喹喔啉骨架的荧光团由于供体和受体基团之间电子离域的增强而表现出改善的光物理性质。这些易于合成的可点击荧光团在蛋白质偶联后成功应用于体外和体内生物成像。
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