Najdawi Wisam, Li Wendy J, De Arrigunaga Sofia, Amer Mona M, Galor Anat, Karp Carol L
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Department of Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL USA.
Curr Ophthalmol Rep. 2025;13(1):8. doi: 10.1007/s40135-025-00335-8. Epub 2025 Jun 21.
Subepithelial lesions of the ocular surface represent a diverse group of pathologies which may be difficult to diagnose clinically. Some of these lesions are relatively uncommon, may result in systemic manifestations, or occur secondary to systemic disease. The purpose of this review is to summarize current approaches to the diagnosis and management of six subepithelial conjunctival lesions.
The standard for the diagnosis of subconjunctival lesions remains histopathologic evaluation; however, high-resolution anterior segment optical coherence tomography (HR-OCT) is a useful supplemental diagnostic tool that may facilitate diagnosis. Recent advancements in the management of subconjunctival lesions include targeted systemic therapies in conjunctival melanoma and ultra-low dose radiation radiotherapy in conjunctival lymphoma.
The development of HR-OCT has provided clinicians with valuable supplemental diagnostic information to guide the diagnosis of subepithelial lesions. Additionally, novel treatment modalities may provide an alternative to traditional surgical interventions in some pathologies.
眼表上皮下病变是一组多样的病理状况，临床诊断可能存在困难。其中一些病变相对罕见，可能导致全身表现，或继发于全身性疾病。本综述旨在总结目前对六种结膜上皮下病变的诊断和管理方法。
结膜下病变的诊断标准仍然是组织病理学评估；然而，高分辨率眼前节光学相干断层扫描（HR-OCT）是一种有用的辅助诊断工具，可有助于诊断。结膜下病变管理的最新进展包括结膜黑色素瘤的靶向全身治疗和结膜淋巴瘤的超低剂量放射治疗。
HR-OCT的发展为临床医生提供了有价值的辅助诊断信息，以指导上皮下病变的诊断。此外，在某些病理情况下，新型治疗方式可能为传统手术干预提供替代方案。
