Zhao Jin-Wei, Zhao Wei-Yi, Yu Zhongyang
Department of Hepatopancreatobiliary Surgery of Second Hospital of Jilin University, Jilin University, Changchun, China.
Department of Cardiology, Jilin Airport Hospital, Jilin, China.
Front Oncol. 2025 Jun 9;15:1568391. doi: 10.3389/fonc.2025.1568391. eCollection 2025.
Ferroptosis is distinctive type programmed cell death. Tumor cells, with their higher iron levels, render them more susceptible to ferroptosis Inducing ferroptosis can activate immune cells, regulate immune evasion, and inhibit the biology activity of cancer cells. Therefore, ferroptosis-induced cancer cell death could become a promising approach for cancer treatment. Dietary compounds are an important source for drug discovery, and there has been an increasing amount of literature on food-derived ferroptosis inducers and their applications in cancer treatment. This review provides an overview of the regulatory mechanisms involved in ferroptosis, explores the mechanisms by which dietary compounds act as ferroptosis inducers, and discusses their effects on various cancers, especially by accumulating lipid ROS and overloading Fe2+, along with inhibiting GPX4 expression to promote ferroptosis in tumors. Additionally, the latest advancements in new methods for inducing ferroptosis, including the use of nanomaterials, are also summarized. Finally, the challenges and opportunities of developing dietary compounds as ferroptosis inducers are discussed, focusing on the discovery of new targets, enhancing selectivity, as well as reducing toxicity and the recurrence of side effects. As far as we know, this is the first comprehensive and systematic summary on the anticancer effects and mechanisms of food-derived ferroptosis inducers.
铁死亡是一种独特类型的程序性细胞死亡。肿瘤细胞铁含量较高，使其更容易发生铁死亡。诱导铁死亡可激活免疫细胞、调节免疫逃逸并抑制癌细胞的生物学活性。因此，铁死亡诱导的癌细胞死亡可能成为一种有前景的癌症治疗方法。膳食化合物是药物发现的重要来源，关于食物源性铁死亡诱导剂及其在癌症治疗中的应用的文献越来越多。本文综述了铁死亡相关的调控机制，探讨了膳食化合物作为铁死亡诱导剂的作用机制，并讨论了它们对各种癌症的影响，特别是通过积累脂质活性氧和使Fe2+过载，以及抑制GPX4表达来促进肿瘤中的铁死亡。此外，还总结了诱导铁死亡新方法（包括使用纳米材料）的最新进展。最后，讨论了将膳食化合物开发为铁死亡诱导剂的挑战和机遇，重点在于发现新靶点、提高选择性以及降低毒性和副作用的复发。据我们所知，这是关于食物源性铁死亡诱导剂抗癌作用和机制的首次全面系统总结。
