Cheng Zilin, Qiao Zeyun, An Shaojie, Liu Jinghua, Ma Wenyi, Hao Pingsheng
Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People's Republic of China.
Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jun 19;18:1507-1519. doi: 10.2147/CCID.S525492. eCollection 2025.
Actinic keratosis (AK) is a precancerous intraepidermal lesion characterized by atypical keratinocyte proliferation. In recent years, research on AK has made continuous progress, but there has been no bibliometric study on it. This study aims to use bibliometric methods to analyze the research and treatment hotspots of AK in recent years, in order to further understand the development direction and frontiers of this field.
Core literature related to AK was retrieved from the Web of Science Core Collection (WoSCC) database. CiteSpace and VOSviewer software were employed to conduct a detailed analysis based on publication output, countries/regions, research institutions, journals, authors, and keywords.
A total of 2,796 documents were included in this study. The United States, Germany, and Italy emerged as the leading contributors to AK research, with the University of Copenhagen identified as the most prolific research institution. Among authors, Pellacani G has published the highest number of articles, while the Journal of the European Academy of Dermatology and Venereology ranks as the most influential journal in this field. The main research hotspots and frontiers in the field of AK are as follows: (1) Molecular mechanisms of malignant transformation to cutaneous squamous cell carcinoma (cSCC), particularly involving genomic instability (eg, TP53 mutations); (2) Personalized therapies optimized through immune profiling, genetic biomarkers, and lesion morphology; (3) Emerging frontiers include non-invasive diagnostic technologies and treatment monitoring, which are receiving significant attention.
This study summarizes the current research status and key areas of focus in AK, providing a foundation for clinical decision-making and guiding future research directions.
光化性角化病（AK）是一种癌前表皮内病变，其特征为非典型角质形成细胞增殖。近年来，关于AK的研究不断取得进展，但尚未有对其的文献计量学研究。本研究旨在运用文献计量学方法分析近年来AK的研究及治疗热点，以进一步了解该领域的发展方向和前沿。
从Web of Science核心合集（WoSCC）数据库中检索与AK相关的核心文献。采用CiteSpace和VOSviewer软件，基于发表产出、国家/地区、研究机构、期刊、作者及关键词进行详细分析。
本研究共纳入2796篇文献。美国、德国和意大利是AK研究的主要贡献国，哥本哈根大学是发文量最多的研究机构。在作者中，佩拉卡尼·G发表的文章数量最多，而《欧洲皮肤病与性病学会杂志》是该领域最具影响力的期刊。AK领域的主要研究热点和前沿如下：（1）向皮肤鳞状细胞癌（cSCC）恶性转化的分子机制，尤其涉及基因组不稳定（如TP53突变）；（2）通过免疫分析、遗传生物标志物和病变形态优化的个性化治疗；（3）新兴前沿包括非侵入性诊断技术和治疗监测，正受到广泛关注。
本研究总结了AK的当前研究现状和重点关注领域，为临床决策提供了依据，并指导未来研究方向。
