Furuse A, Hiramatsu M, Adachi N, Karashima S, Hattori S, Matsuda I
Int J Pediatr Nephrol. 1985 Jul-Sep;6(3):205-8.
We report a dramatic response of the nephrotic syndrome to prednisolone therapy (2 mg per kg per day) in a 6-year-old boy with IgA nephropathy. He had developed massive proteinuria (22.1 gm per day) and microscopic hematuria shortly after an episode of tonsillitis. Renal biopsy two months after onset showed mild mesangial hypercellularity with typical mesangial deposition of IgA. Corticosteroid therapy resulted in a sharp cessation of proteinuria and complete resolution of the urinary abnormalities. We suggest that massive proteinuria associated with IgA nephropathy may be responsive to corticosteroid therapy when there are minimal glomerular changes.
我们报告了一名患有IgA肾病的6岁男孩，其肾病综合征对泼尼松龙治疗（每日每公斤体重2毫克）有显著反应。在一次扁桃体炎发作后不久，他出现了大量蛋白尿（每日22.1克）和镜下血尿。发病两个月后进行的肾活检显示轻度系膜细胞增多，伴有典型的IgA系膜沉积。皮质类固醇治疗导致蛋白尿急剧停止，尿液异常完全消失。我们认为，当肾小球变化很小时，与IgA肾病相关的大量蛋白尿可能对皮质类固醇治疗有反应。
