Morris Alan W J, Mueller Raeghan L, Sempio Cristina, Klawitter Jost, Bryan Angela D, Bidwell L Cinnamon, Hutchison Kent E
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Department of Anesthesiology, iC42 Clinical Research and Development, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Cannabis Cannabinoid Res. 2025 Aug;10(4):506-511. doi: 10.1089/can.2024.0175. Epub 2025 Jun 24.
Eicosanoids-lipid mediators derived from polyunsaturated fatty acids such as arachidonic acid-have a notable role in inflammatory signaling. Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have been shown in preclinical studies to modulate inflammatory pathways the modulating the enzymes that generate eicosanoids, namely lipoxygenase (LOX), cyclooxygenase (COX), and cytochrome P450 (CYP450). This present study aimed to investigate how CBD and THC effect plasma levels of eicosanoids generated through LOX, COX, and cytochrome P450 (CYP450) pathways. Using plasma sample data from multiple clinical studies, we tested the hypothesis that high-CBD cannabis use would increase eicosanoid levels compared with high-THC cannabis. Following cannabis use, high-CBD cannabis led to a rise in plasma eicosanoids, particularly lipoxins, while high-THC cannabis did not. CBD promoted anti-inflammatory eicosanoid production the 15-LOX pathway, therefore supporting the potential role of CBD as a therapeutic candidate for inflammatory diseases.
类二十烷酸——源自多不饱和脂肪酸（如花生四烯酸）的脂质介质——在炎症信号传导中发挥着显著作用。临床前研究表明，大麻二酚（CBD）和Δ9-四氢大麻酚（THC）可通过调节生成类二十烷酸的酶，即脂氧合酶（LOX）、环氧化酶（COX）和细胞色素P450（CYP450）来调节炎症通路。本研究旨在探究CBD和THC如何影响通过LOX、COX和细胞色素P450（CYP450）途径生成的类二十烷酸的血浆水平。利用多项临床研究的血浆样本数据，我们检验了以下假设：与高THC大麻相比，高CBD大麻的使用会增加类二十烷酸水平。使用大麻后，高CBD大麻导致血浆类二十烷酸水平升高，尤其是脂氧素，而高THC大麻则没有。CBD通过15-LOX途径促进抗炎类二十烷酸的产生，因此支持了CBD作为炎症性疾病治疗候选药物的潜在作用。
