Barman Bhupen, Sathees Varsha, Nune Arvind, Chakrabarty Anomitro, Das Jayanta, Dange Prasad
Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Guwahati, Assam, India, Corresponding Author, Orcid: https://orcid.org/0000-0002-5433-1310.
Resident, Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India, Orcid: https://orcid.org/0000-0001-8218-0620.
J Assoc Physicians India. 2025 Jun;73(6):29-33. doi: 10.59556/japi.73.1020.
This prospective study was designed to evaluate the utility of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in the assessment of disease activity in rheumatoid arthritis (RA).
A prospective, analytical, hospital-based study was conducted in which adult patients of RA, alongside healthy controls, were included.
In this study involving 74 patients of RA and 74 healthy controls, statistically significant differences were noted between hematological parameters of both groups. Significant positive correlations were found between NLR and disease activity score 28 (DAS28) ( = 0.84, = 0.001), erythrocyte sedimentation rate (ESR) ( = 0.94, = 0.001), and C-reactive protein (CRP) ( = 0.8, = 0.01), and between PLR and DAS28 ( = 0.79, = 0.025) in patients. Receiver operating characteristic (ROC) curves of NLR and PLR against disease activity of patients showed area under the curves (AUCs) of 0.92 and 0.89, sensitivity of 91 and 83%, and specificity of 84 and 83%, respectively.
NLR and PLR demonstrate significant positive correlations with disease activity in RA, suggesting their potential as reliable indices for assessing disease severity and facilitating early management initiation.
本前瞻性研究旨在评估中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在评估类风湿关节炎（RA）疾病活动度方面的效用。
开展了一项基于医院的前瞻性分析研究，纳入了成年RA患者以及健康对照者。
在这项涉及74例RA患者和74名健康对照者的研究中，两组的血液学参数存在统计学显著差异。患者的NLR与疾病活动度评分28（DAS28）（r = 0.84，P = 0.001）、红细胞沉降率（ESR）（r = 0.94，P = 0.001）和C反应蛋白（CRP）（r = 0.8，P = 0.01）之间，以及PLR与DAS28（r = 0.79，P = 0.025）之间均发现显著正相关。NLR和PLR针对患者疾病活动度的受试者工作特征（ROC）曲线显示，曲线下面积（AUC）分别为0.92和0.89，灵敏度分别为91%和83%，特异性分别为84%和83%。
NLR和PLR与RA疾病活动度呈显著正相关，表明它们有可能作为评估疾病严重程度和促进早期开始治疗的可靠指标。
