沉默的伪装者：阵发性夜间血红蛋白尿症被揭示。
The Silent Masquerader: Paroxysmal Nocturnal Hemoglobinuria Revealed.
作者信息
Hegde Akshay S, Rajanna Avinash H, Kavya S T, Kanth Mahesh S
机构信息
Post Graduate, Department of General Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India, Corresponding Author.
Assistant Professor, Department of General Medicine, Shri Atal Bihari Vajpayee Medical College and Research Institute, Bengaluru, Karnataka, India.
出版信息
J Assoc Physicians India. 2025 Jun;73(6):77-81. doi: 10.59556/japi.73.1006.
Paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hematological disease, is identified by chronic hemolysis due to uncontrolled complement activation. We are reporting three cases-case 1: a 30-year-old male with hemolytic anemia and recurrent hospitalizations for blood transfusion who came with easy fatigability, breathlessness, jaundice, and pedal edema. Case 2: a 28-year-old female with hemolytic anemia who presented with fever, loose stools, reduced urine output, and hematuria. Case 3: a 37-year-old male presented with easy fatigability and jaundice and had splenomegaly on examination. All three cases were positive for different PNH clones on flow cytometry.
阵发性睡眠性血红蛋白尿症（PNH）是一种罕见的后天性血液疾病，其特征为由于补体激活失控导致慢性溶血。我们报告三例病例——病例1：一名30岁男性，患有溶血性贫血，因反复输血住院，前来就诊时伴有易疲劳、呼吸急促、黄疸和足部水肿。病例2：一名28岁女性，患有溶血性贫血，表现为发热、腹泻、尿量减少和血尿。病例3：一名37岁男性，表现为易疲劳和黄疸，检查发现脾肿大。所有三例病例经流式细胞术检测，不同的PNH克隆均呈阳性。
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