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一名绝对免疫功能正常患者肺炎的惊人病因

A Surprising Culprit of Pneumonia in an Absolute Immunocompetent Patient.

作者信息

Agarwal Sujal R, Jangid Abhinandan, Surkunda Shashikala T, Ballal Arjun N, Stanley Weena

机构信息

MBBS Student, Department of Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, Orcid: https://orcid.org/0009-0006-7609-0067.

MBBS Student, Department of Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, Orcid: https://orcid.org/0009-0009-0265-9670.

出版信息

J Assoc Physicians India. 2025 Jun;73(6):82-84. doi: 10.59556/japi.73.1017.

DOI:10.59556/japi.73.1017
PMID:40553598
Abstract

INTRODUCTION

a gram-positive coccus and typical resident of the oropharyngeal and upper respiratory system, has increasingly been recognized as a human pathogen since its first identification in 1978. While it commonly affects immunocompromised individuals, causing serious infections like endocarditis, septicemia, and pneumonia, infection in immunocompetent hosts is rare. This article presents a case of pneumonia caused by in an immunocompetent individual.

CASE DESCRIPTION

A 42-year-old male with no significant medical history presented with a persistent cough and high-grade fever. Investigations revealed elevated neutrophils, C-reactive protein (CRP), and high-resolution computed tomography (HRCT) thorax indicating multifocal consolidation. Empirical management with piperacillin-tazobactam and clindamycin was ineffective, leading to a switch to meropenem-sulbactam. Bronchoalveolar lavage (BAL) identified prompting cotrimoxazole therapy. The patient's fever subsided, and inflammatory markers decreased. After a 2-week course and follow-up, the patient exhibited no symptoms or recurrence of infection and remained stable.

DISCUSSION

primarily affects immunocompromised individuals or those with underlying comorbidities. Diagnosis requires careful specimen collection and identification techniques. Treatment is challenging due to variable antibiotic susceptibility, with vancomycin, third-generation cephalosporins, and rifampicin often used. The pathogen's ability to cause pneumonia in healthy individuals without comorbidities remains unreported. Underreporting due to misidentification and the need for awareness among clinicians are significant concerns in managing infections.

CONCLUSION

R. mucilaginosa is a significant pathogen causing pneumonia in diverse patient groups. Without formal treatment guidelines, diagnosis relies on clinical experience. Early detection and appropriate antibiotic therapy are crucial for effective management.

摘要

引言

[某种细菌名称未给出]是一种革兰氏阳性球菌,是口咽和上呼吸道系统的典型常驻菌,自1978年首次被鉴定以来,越来越多地被认为是一种人类病原体。虽然它通常感染免疫功能低下的个体,引起心内膜炎、败血症和肺炎等严重感染,但在免疫功能正常的宿主中感染很少见。本文介绍了一例由[该细菌名称未给出]引起的免疫功能正常个体的肺炎病例。

病例描述

一名42岁男性,无重大病史,出现持续咳嗽和高热。检查发现中性粒细胞、C反应蛋白(CRP)升高,胸部高分辨率计算机断层扫描(HRCT)显示多灶性实变。哌拉西林 - 他唑巴坦和克林霉素的经验性治疗无效,导致改用美罗培南 - 舒巴坦。支气管肺泡灌洗(BAL)鉴定出[该细菌名称未给出],促使使用复方新诺明治疗。患者的发热消退,炎症标志物下降。经过2周的疗程和随访,患者没有症状或感染复发,病情保持稳定。

讨论

[该细菌名称未给出]主要影响免疫功能低下的个体或有潜在合并症的个体。诊断需要仔细的标本采集和鉴定技术。由于抗生素敏感性多变,治疗具有挑战性,常用万古霉素、第三代头孢菌素和利福平。该病原体在无合并症的健康个体中引起肺炎的能力尚未见报道。由于误识别导致的报告不足以及临床医生需要提高认识是管理[该细菌名称未给出]感染的重大问题。

结论

黏液罗氏菌是导致不同患者群体肺炎的重要病原体。由于没有正式的治疗指南,诊断依赖于临床经验。早期检测和适当的抗生素治疗对于有效管理至关重要。

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