Al-Haidary Yahya Ali Desher, Glayl Ahmed Ghanim, Al-Maliky Sajjad Abbas Khairullah, Al Regebat Zainab Hasan, Abdul-Zahr Dalel Saad
Imam Al-Sadiq Teaching Hospital, Babylon, 51001, Iraq.
Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, F-91400, France; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, F-91400, France; Al - Nasiriyah Teaching Hospital, Thi Qar Health Directorate, Iraq.
Appl Radiat Isot. 2025 Nov;225:111983. doi: 10.1016/j.apradiso.2025.111983. Epub 2025 Jun 10.
Breast cancer (BC) is a highly prevalent and significant health concern influencing women worldwide. This is crucial for understanding the impact of breast cancer and developing targeted prevention and treatment strategies. The research aims to investigate the performance of the 3DCRT model by comparing BCS and MRM plans in terms of mean lung dose.
A comparative analysis of MRM and BCS treatment plans was conducted to determine the most appropriate strategy for breast cancer, with an emphasis on minimizing radiation dose to the lungs.
Breast cancer (BC) RT was performed for 174 patients' treatment planning. The treatment plans for BCS are compared to the MRM plans based on mean dose lung and target coverage. To create a 3DCRT plan for Breast cancer, applying 3DCRT in Monaco and evaluating an outcome of Breast cancer irradiation procedure, analyse the main dosimetric parameters of the planned treatment plans for BCS and MRM plans. This study divided the patients into two groups according to the type of surgery breast-conserving surgery (BCS) and modified radical mastectomy (MRM) groups. Each group is also divided into different subgroups according to the dose of radiotherapy given (4050, 4256, and 5000 cGy) and whether the lymph nodes in the axillae and the supraclavicular regions are irradiated or not have been taken into account. Different strategy plans were performed to get the best result according to the size of the PTV. The dose Prescribed for MRM was 4050 cGy, 270 cGy per fraction (270 cGy/Fx), 4256/16 fraction while BCS was 5000 cGy, 200 cGy per fraction (200 cGy/Fx), 4050/15 fraction 270 cGy per fraction (270 cGy/Fx).
The total number of patients in this study was 174 breast cancer patients with ages ranging from 18 to 77 years with a mean age ± SD (49.2 ± 11.5) years, and the results showed the highest incidence of breast cancer among patients in 6th (50-59 years) and they are (29.3 %) and the 5th and 7th decades of life and (23.5 %) each, while the lowest incidence of breast cancer among patients in 3rd decade of life (below 1 %).
乳腺癌（BC）是一种高度普遍且严重影响全球女性健康的疾病。这对于理解乳腺癌的影响以及制定针对性的预防和治疗策略至关重要。本研究旨在通过比较保乳手术（BCS）和改良根治性乳房切除术（MRM）计划的平均肺剂量来研究三维适形放疗（3DCRT）模型的性能。
对MRM和BCS治疗计划进行对比分析，以确定针对乳腺癌的最合适策略，重点是将肺部的辐射剂量降至最低。
对174例乳腺癌患者进行放疗治疗计划。基于平均肺剂量和靶区覆盖情况，将BCS的治疗计划与MRM计划进行比较。为乳腺癌创建一个3DCRT计划，在Monaco中应用3DCRT并评估乳腺癌放疗程序的结果，分析BCS和MRM计划的计划治疗计划的主要剂量学参数。本研究根据手术类型将患者分为两组，即保乳手术（BCS）组和改良根治性乳房切除术（MRM）组。每组还根据给予的放射治疗剂量（4050、4256和5000厘戈瑞）以及腋窝和锁骨上区域的淋巴结是否接受照射进一步分为不同亚组。根据计划靶体积（PTV）的大小执行不同的策略计划以获得最佳结果。MRM规定的剂量为4050厘戈瑞，每次分割270厘戈瑞（270厘戈瑞/分次），4256厘戈瑞分16次分割，而BCS为5000厘戈瑞，每次分割200厘戈瑞（200厘戈瑞/分次），4050厘戈瑞分15次分割，每次分割270厘戈瑞（270厘戈瑞/分次）。
本研究的患者总数为174例乳腺癌患者，年龄范围为18至77岁，平均年龄±标准差为（49.2±11.5）岁，结果显示乳腺癌发病率最高的是60岁（50 - 59岁）的患者，占比（29.3%），其次是50岁和70岁年龄段的患者，各占（23.5%），而30岁年龄段的患者中乳腺癌发病率最低（低于1%）。
