Zhang Yan, Zhou Yaqian, Liu Ping, Zhang Yufeng, Wan Yiqun, Liu Fan, Sun Genlin, Chen Lihua, Wang Jun
Jiangxi University of Chinese Medicine, Nanchang 330031, Jiangxi, PR China.
Chemistry and Chemical Engineering School, Nanchang University, Nanchang 330031, Jiangxi, PR China.
J Chromatogr A. 2025 Aug 30;1757:466152. doi: 10.1016/j.chroma.2025.466152. Epub 2025 Jun 15.
A rapid and efficient method is highly desired for the determination of phenylurea herbicides (PUHs) in edible and medicinal herbs. Herein, we report a dispersive solid-phase extraction (d-SPE) method using a metal-organic framework ZnO(NTB) as the adsorbent. The microporous ZnO(NTB) can selectively extract targets while excluding matrix substances. Under optimized conditions, this method exhibits high sensitivity, with a limit of detections (LODs) and limits of quantification (LOQs) in the range of 0.09-0.32 ng mL and 0.32-1.08 ng mL, respectively. Moreover, the recoveries reach the range of 69.8 %-83.3 % with relative standard deviations below 6.2 %. The optimized adsorption efficiency of PUHs can be rapidly achieved in a short time of 10 min. Additionally, the adsorbent can be facilely regenerated with methanol washing. Furthermore, computational simulations reveal the guest-host interactions involving hydrogen bonding, π-π stacking interactions, and Van der Waals interactions. Practically, the established method has been successfully validated for extracting PUHs from Dendrobium candidum and Ganoderma lucidum samples.
一种快速高效的方法对于测定食用和药用草药中的苯基脲类除草剂（PUHs）来说是非常需要的。在此，我们报道一种使用金属有机框架ZnO(NTB)作为吸附剂的分散固相萃取（d-SPE）方法。微孔ZnO(NTB)能够选择性地萃取目标物，同时排除基质物质。在优化条件下，该方法具有高灵敏度，检测限（LODs）和定量限（LOQs）分别在0.09 - 0.32 ng/mL和0.32 - 1.08 ng/mL范围内。此外，回收率达到69.8% - 83.3%，相对标准偏差低于6.2%。在10分钟的短时间内即可快速实现PUHs的优化吸附效率。另外，吸附剂用甲醇洗涤即可轻松再生。此外，计算模拟揭示了包括氢键、π-π堆积相互作用和范德华相互作用在内的客体-主体相互作用。实际上，所建立的方法已成功验证可用于从铁皮石斛和灵芝样品中萃取PUHs。
