Tarekegn Tenaw Baye, Alemkere Getachew, Ali Eskinder Eshetu
Department of Pharmacy, College of Health Sciences, Woldia University, Woldia, Ethiopia.
School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
PLoS One. 2025 Jun 24;20(6):e0326033. doi: 10.1371/journal.pone.0326033. eCollection 2025.
Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.
A cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.
Anxiety/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD ± 0.14), and the mean EQ-VAS score was 80.6 (SD ± 15.6). Older age (55-64 years: β = -0.067, p < 0.001; ≥ 65 years: β = -0.383, p < 0.001) and unemployment (β = -0.119, p < 0.001) were associated with significantly lower HRQoL. Conversely, higher income (β = 0.056, p < 0.001), absence of comorbidities (β = 0.059, p < 0.001), and mid-treatment duration (4-5 months: β = 0.029, p = 0.011) correlated with better HRQoL.
The findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support.
结核病严重损害健康相关生活质量（HRQoL），但使用EQ-5D工具评估其对埃塞俄比亚患者影响的研究有限。本研究评估埃塞俄比亚结核病患者的HRQoL，估计健康状态效用值，并确定相关因素。
在埃塞俄比亚亚的斯亚贝巴的20个公共卫生中心进行了一项横断面研究，纳入通过比例分配选取的672例结核病患者。使用欧洲五维度五水平（EQ-5D-5L）工具测量HRQoL。使用Kruskal-Wallis检验和Tobit删失回归模型分析效用得分的预测因素。
焦虑/抑郁是受影响最频繁的维度（55.4%的参与者）。EQ-5D-5L效用得分的平均值为0.91（标准差±0.14），EQ-VAS得分的平均值为80.6（标准差±15.6）。年龄较大（55 - 64岁：β = -0.067，p < 0.001；≥65岁：β = -0.383，p < 0.001）和失业（β = -0.119，p < 0.001）与显著较低的HRQoL相关。相反，较高收入（β = 0.056，p < 0.001）、无合并症（β = 0.059，p < 0.001）和治疗中期（4 - 5个月：β = 0.029，p = 0.011）与较好的HRQoL相关。
研究结果强调了社会人口学和临床因素对埃塞俄比亚结核病患者HRQoL的影响，呼吁采取有针对性的干预措施和政策改革，以改善治疗效果并加强患者支持。
