Yasobant Sandul, Nazli Khatib Mahalaqua, Syed Zahiruddin Quazi, Gaidhane Abhay M, Shah Harsh, Narkhede Kiran, Bhavsar Priya, Patel Jay, Sinha Anish, Puwar Tapasvi, Saha Somen, Saxena Deepak
Department of Public Health Science, Indian Institute of Public Health Gandhinagar (IIPHG), Gandhinagar 382042, India.
School of Epidemiology and Public Health, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha 442004, India.
Infect Dis Rep. 2022 Jul 18;14(4):509-524. doi: 10.3390/idr14040055.
Tuberculosis (TB) is a major killer and cause of human suffering worldwide and imposes a substantial reduction in patients' health-related quality of life (HRQoL). HRQoL indicates the consciousness of patients regarding their physical and mental health. It is, therefore, very relevant in comprehending and measuring the exact impact of the disease state. Therefore, we undertook this review to summarize the available evidence on the impact of TB and its treatment on HRQoL. An in-depth understanding of HRQoL in TB patients can identify the existing management gaps. We undertook a systematic search through PubMed and CENTRAL. Data were extracted and tabulated for study design, targeted population, QoL instrument used, QoL domain assessed, and key findings. We included studies that assessed the effect of TB on the QoL both during and after treatment. There are no specific HRQoL assessment tools for utilization among TB patients. HRQoL is markedly impaired in patients with TB. The factors affecting HRQoL differ with active and latent TB, socio-demographics, socio-economic status, presence of co-infections, etc. This review's findings can help to frame appropriate policies for tackling HRQoL issues in TB patients.
结核病是全球主要的致死病因，给人类带来巨大痛苦，严重降低了患者的健康相关生活质量（HRQoL）。HRQoL反映了患者对自身身心健康的认知。因此，它对于理解和衡量疾病状态的确切影响非常重要。所以，我们进行了本次综述，以总结关于结核病及其治疗对HRQoL影响的现有证据。深入了解结核病患者的HRQoL可以发现现有管理中的差距。我们通过PubMed和CENTRAL进行了系统检索。提取数据并制成表格，内容包括研究设计、目标人群、使用的生活质量工具、评估的生活质量领域以及主要发现。我们纳入了评估结核病在治疗期间和治疗后对生活质量影响的研究。目前尚无专门用于结核病患者的HRQoL评估工具。结核病患者的HRQoL明显受损。影响HRQoL的因素因活动性和潜伏性结核病、社会人口统计学、社会经济状况、合并感染的存在等而有所不同。本综述的结果有助于制定应对结核病患者HRQoL问题的适当政策。
