Findlay P A, Wright D C, Rosenow U, Harrington F S, Miller R W
Int J Radiat Oncol Biol Phys. 1985 Nov;11(11):2021-6. doi: 10.1016/0360-3016(85)90287-1.
Use of interstitial radiation holds promise in the treatment of primary malignant brain tumors, but optimal technical factors have yet to be determined. We have developed a method of precise CT directed stereotactic placement of radioactive sources in a predetermined target volume. We use low activity (1-2 millicurie/speed) sources of 125I loaded in silastic catheters, which are positioned in a parallel array in the target. Positioning of such multiple sources toward the periphery of the volume enhances achievable dose homogeneity. Seeds of various activities can be differentially loaded into each catheter and the catheters can be positioned at various radii from the central target so that the treated volume corresponds to the identified (often irregular) target volume. Although the implant is designed to be permanent, the sources can be removed easily in a second procedure.
间质放射疗法在原发性恶性脑肿瘤的治疗中具有前景，但最佳技术因素尚未确定。我们已开发出一种方法，可在预定靶体积内通过CT精确引导进行放射性源的立体定向放置。我们使用低活度（1 - 2毫居里/速度）的125I源，将其装入硅橡胶导管中，这些导管在靶区内以平行阵列排列。将多个这样的源放置在体积的周边可提高可实现的剂量均匀性。可以将不同活度的籽源分别装入每个导管，并且导管可以放置在距中心靶不同半径处，以便治疗体积与确定的（通常不规则的）靶体积相对应。尽管植入物设计为永久性的，但在第二次手术中可以轻松取出这些源。
