Department of Radiation Oncology, Ludwig-Maximilians-University Hospital, Marchioninistr, 15, 81377 Munich, Germany.
Radiat Oncol. 2012 Mar 6;7:30. doi: 10.1186/1748-717X-7-30.
Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined.An extensive review of the literature has been performed, especially concerning indications, results and complications. Iodine-125 seeds have been implanted in astrocytomas I-III, glioblastomas, metastases and several other tumour entities. Outcome data given in the literature are summarized. Complications are rare in carefully selected patients.All in all, for highly selected patients with newly diagnosed or recurrent primary or metastatic tumours, this method provides encouraging survival rates with relatively low complication rates and a good quality of life.
碘-125 近距离放疗自 1979 年以来已应用于脑肿瘤。尽管物理和生物学特性使这些植入物特别适合微创治疗，但立体定向近距离放疗的应用仍未得到明确界定。我们对文献进行了广泛的回顾，特别是关于适应证、结果和并发症。碘-125 种子已植入星形细胞瘤 I-III、胶质母细胞瘤、转移瘤和其他几种肿瘤实体。文献中给出的结果数据进行了总结。在仔细选择的患者中，并发症罕见。总之，对于新诊断或复发性原发性或转移性肿瘤的高度选择患者，这种方法提供了令人鼓舞的生存率，相对较低的并发症发生率和良好的生活质量。
