Liu Jiamin, Yang Wenbo, Song Lijun, Chen Xianjin, Yin Xiayan, Li Mingan, Bai Xiaoyan, Yang Zhenghan, Wang Zhenchang, Guo Weikang, Wang Hao, Wang Gang
Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ren Fail. 2025 Dec;47(1):2521454. doi: 10.1080/0886022X.2025.2521454. Epub 2025 Jun 24.
The incidence of cognitive impairment in patients with peritoneal dialysis (PD) and hemodialysis (HD) has been increased, but the specific mechanism is not clear. Disruption of iron homeostasis is associated with cognitive impairment. This study aimed to explore the relationship between brain iron deposition and cognitive impairment in patients with PD and HD by using quantitative susceptibility mapping (QSM).
The cross-sectional study enrolled 56 PD patients, 66 HD patients, and 56 age-sex matched healthy controls. All participants underwent QSM to measure brain iron content and Montreal Cognitive Assessment (MoCA) to assess cognitive function. In addition, relevant biochemical indicators were collected and analyzed. The ANOVA was used to test for differences in susceptibility value among bilateral caudate nuclei (CAU), thalamus (THA), putamen and pallidum. Pearson correlation analysis was performed to investigate the relationships between susceptibility value and clinical laboratory parameters or MoCA score.
Compared with HC, PD patients showed higher susceptibility value in bilateral CAU and left THA. Compared with HD patients, PD patients showed higher susceptibility value in left THA. PD patients showed a negative correlation between susceptibility value and MoCA score.
There are different patterns of brain iron deposition in PD and HD patients. Abnormal brain iron deposition in PD patients may be associated with cognitive impairment.
腹膜透析（PD）和血液透析（HD）患者认知障碍的发生率有所增加，但具体机制尚不清楚。铁稳态失衡与认知障碍有关。本研究旨在通过使用定量磁化率成像（QSM）探讨PD和HD患者脑铁沉积与认知障碍之间的关系。
这项横断面研究纳入了56例PD患者、66例HD患者和56例年龄和性别匹配的健康对照者。所有参与者均接受QSM以测量脑铁含量，并接受蒙特利尔认知评估（MoCA）以评估认知功能。此外，收集并分析相关生化指标。采用方差分析检验双侧尾状核（CAU）、丘脑（THA）、壳核和苍白球之间磁化率值的差异。进行Pearson相关分析以研究磁化率值与临床实验室参数或MoCA评分之间的关系。
与健康对照者相比，PD患者双侧CAU和左侧THA的磁化率值更高。与HD患者相比，PD患者左侧THA的磁化率值更高。PD患者的磁化率值与MoCA评分呈负相关。
PD和HD患者存在不同的脑铁沉积模式。PD患者脑铁沉积异常可能与认知障碍有关。
