Portillo-Miño José Dario, Calderón Jhon Jairo, Ruiz-García Erika, Monge Cecilia
Grupo de Investigacion en Enfermedades Infecciosas y Cancer (GINFYCA), Centro de Investigaciones Clinicas, Fundacion Hospital San Pedro, Pasto, Nariño, Colombia.
Biological Sciences Master Program, Faculty of Sciences, Pontificia Universidad Javeriana, Bogota D.C, Colombia.
Clin Transl Oncol. 2025 Jun 24. doi: 10.1007/s12094-025-03960-8.
Gastric cancer (GC) exhibits aggressive behavior and high mortality rates globally. In this respect, the effectiveness of chemotherapy and immunotherapy is hindered by various factors including tumor heterogeneity, immune phenotypes, chronic H. pylori infection, and an immunosuppressive tumor microenvironment (TME). The immunosuppressive TME is fostered by multiple immune cell subpopulations as tumor-associated neutrophils, tumor-associated macrophages, tumor-associated dendritic cells, regulatory T cells, and myeloid-derived suppressor cells (MDSCs). The MDSC abundantly infiltrates gastric TME, which interacts with H. pylori infection and is influenced by reactive oxygen species (ROS), chronic inflammation, and hypoxia. Understanding its cellular and molecular biology of GC is crucial for developing novel therapeutic options. Current preclinical evidence is emerging to support translational oncology on MDSC immunotherapy. This article review suggests MDSC modulation may be a promising avenue for enhancing chemotherapy and immunotherapy responses against GC.
胃癌（GC）在全球范围内表现出侵袭性生物学行为和高死亡率。在这方面，化疗和免疫疗法的有效性受到多种因素的阻碍，包括肿瘤异质性、免疫表型、幽门螺杆菌慢性感染以及免疫抑制性肿瘤微环境（TME）。免疫抑制性TME由多种免疫细胞亚群促成，如肿瘤相关中性粒细胞、肿瘤相关巨噬细胞、肿瘤相关树突状细胞、调节性T细胞和髓源性抑制细胞（MDSC）。MDSC大量浸润胃TME，它与幽门螺杆菌感染相互作用，并受活性氧（ROS）、慢性炎症和缺氧影响。了解其在GC中的细胞和分子生物学对于开发新的治疗方案至关重要。目前正在出现临床前证据来支持MDSC免疫疗法的转化肿瘤学研究。本文综述表明，调节MDSC可能是增强针对GC的化疗和免疫疗法反应的一个有前景的途径。
