Piani Federica, Annesi Lorenzo, Borghi Claudio
Hypertension and Cardiovascular Risk Research Centre, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna Bologna, Italy.
Eur Cardiol. 2025 Jun 12;20:e18. doi: 10.15420/ecr.2024.30. eCollection 2025.
The role of hyperuricaemia as an independent cardiovascular risk factor remains controversial and subject to debate. Nonetheless, multiple studies have highlighted the central role of uric acid (UA) in conditions such as hypertension, metabolic syndrome, heart failure and coronary artery disease. Various mechanisms have been proposed to explain UA's involvement in cardiovascular diseases, including through UA-induced oxidative stress, systemic inflammation, endothelial dysfunction and activation of the renin-angiotensin-aldosterone system (RAAS). Asymptomatic hyperuricaemia has been proposed as an independent risk factor for ischaemic heart disease. Nonetheless, the positive impact of urate-lowering therapies on reducing cardiovascular risk still needs to be thoroughly confirmed through large randomised controlled studies.
高尿酸血症作为一个独立的心血管危险因素，其作用仍存在争议且有待讨论。尽管如此，多项研究已强调尿酸（UA）在高血压、代谢综合征、心力衰竭和冠状动脉疾病等病症中的核心作用。已提出多种机制来解释UA参与心血管疾病的过程，包括通过UA诱导的氧化应激、全身炎症、内皮功能障碍以及肾素 - 血管紧张素 - 醛固酮系统（RAAS）的激活。无症状高尿酸血症已被提出是缺血性心脏病的一个独立危险因素。尽管如此，降尿酸治疗对降低心血管风险的积极影响仍需通过大型随机对照研究来彻底证实。
