Abdelli F Z, Ouaddane Alami S, Khalfi S, Soussy K, Hassani W, Farhane F Z, Alami Z, Bouhafa T
Radiation Therapy Department, Hassan II University Hospital, Fes 30050, Morocco.
Ecancermedicalscience. 2025 May 29;19:1918. doi: 10.3332/ecancer.2025.1918. eCollection 2025.
Germinoma (called seminoma in the testis and dysgerminoma in the ovary) is the neoplastic side of the primitive germ cell. It may be of gonadal or extragonadal origin, although intracranial location remains rare (between 0.5% and 3.2% in adults), 2/3 of which are located in the pineal region. We report a case of a patient with a seminoma of the pineal gland. Symptoms included headache, vomiting and diplopia. The work-up was negative. The patient was initially treated with bleomycin, etoposide and platinum protocol chemotherapy. The tumour was deemed inaccessible to surgery, which is why the patient underwent three-dimensional conformal radiotherapy with a dose of 24 Gy in 12 fractions to the tri-ventricular system, followed by a 16 Gy boost to the pineal region. Pineal neoplasms are rare. Its prognosis has been considerably improved thanks to a multidisciplinary approach. However, radiotherapy remains a good alternative approach.
生殖细胞瘤（在睾丸称为精原细胞瘤，在卵巢称为无性细胞瘤）是原始生殖细胞的肿瘤性病变。它可能起源于性腺或性腺外，尽管颅内生殖细胞瘤仍然罕见（在成人中占0.5%至3.2%），其中三分之二位于松果体区。我们报告一例松果体区精原细胞瘤患者。症状包括头痛、呕吐和复视。检查结果为阴性。患者最初接受博来霉素、依托泊苷和顺铂方案化疗。该肿瘤被认为无法手术切除，因此患者接受了三维适形放疗，三脑室系统分12次给予24 Gy剂量，随后对松果体区追加16 Gy剂量。松果体肿瘤罕见。由于多学科方法，其预后有了显著改善。然而，放疗仍然是一种很好的替代方法。
