Spar J A, La Rue A
J Clin Psychiatry. 1985 Nov;46(11):466-9.
Acute response to a single-dose, nonblind administration of methylphenidate 20 mg predicted outcome of treatment with desipramine in 42 elderly depressed inpatients. Treatment outcome was not predicted by the methylphenidate challenge in 29 patients who received amitriptyline. These findings are consistent with Maas' biogenic amine hypothesis and are encouraging with respect to the clinical utility of the methylphenidate challenge in geriatric depression.
对42名老年住院抑郁症患者单次非盲法服用20毫克哌甲酯的急性反应可预测地昔帕明的治疗结果。在接受阿米替林治疗的29名患者中，哌甲酯激发试验无法预测治疗结果。这些发现与马斯的生物胺假说相符，并且对于哌甲酯激发试验在老年抑郁症中的临床应用来说是令人鼓舞的。
