Koszewska I, Beresewicz M, Puzyński S, Kalinowski A
II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii w Warszawie.
Psychiatr Pol. 1994 Jan-Feb;28(1):27-38.
Comparative studies of the therapeutic activity of amitriptyline, imipramine, desipramine and chlorimipramine were studied in a group of 185 patients with endogenous depression. After standard 28-day treatment, the best results were obtained while using amitriptyline (improvement rate 67%, the greatest reduction in the Hamilton Depression Scale scored on 28-day of the treatment). The profile and characteristics of antidepressive action of all the drugs taken into consideration are comparable (including slightly more expressed sedative and deliberative effects of amitriptyline). Desinhibitive influence of desipramine and imipramine was not proved. Neither was tachythymoleptic activity of desipramine found. The study does not support the relation between the antidepressive action profile of tricyclic antidepressants and their influence on reuptake of monoamines (norepinephrine and serotonine).
对185例内源性抑郁症患者进行了阿米替林、丙咪嗪、地昔帕明和氯米帕明治疗活性的比较研究。经过标准的28天治疗后，使用阿米替林时取得了最佳效果（改善率67%，治疗第28天汉密尔顿抑郁量表得分下降最多）。所有考虑药物的抗抑郁作用特征和特点具有可比性（包括阿米替林的镇静和深思作用略更明显）。未证实地昔帕明和丙咪嗪的去抑制作用。也未发现地昔帕明的抗躁狂活性。该研究不支持三环类抗抑郁药的抗抑郁作用特征与其对单胺（去甲肾上腺素和血清素）再摄取的影响之间的关系。
