Hou Haiyan, Zhu Liying
Department of Infectious Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang, China.
Front Clin Diabetes Healthc. 2025 Jun 10;6:1596938. doi: 10.3389/fcdhc.2025.1596938. eCollection 2025.
Type 2 diabetic osteoporosis (T2DOP) has received considerable attention due to its accelerated bone deterioration and significantly increased fracture risk. Unlike classical osteoporosis, patients with T2DOP often exhibit a paradoxical pattern: they have normal or even elevated bone mineral density (BMD) in early stages despite deterioration in bone microarchitecture. This paradox highlights the clinical importance of identifying T2DOP as a distinct and critical subtype of secondary osteoporosis.
We conducted a bibliometric analysis of literature on T2DOP published over the past 20 Years(from 2001 to 2020), using data retrieved from the Web of Science Core Collection database. Bibliometric networks were visualized and analyzed using VOSviewer. Publication trends, geographic contributions, research hotspots, and keyword clusters were systematically examined.
Over the past 20 Years, global research output on T2DOP steadily increased, with major contributions from North America, East Asia, and Western Europe. Identified research hotspots included risk prediction, biomarkers (e.g., advanced glycation end-products), complication management, population-specific characteristics (e.g., postmenopausal women), and therapeutic strategies (e.g., metformin). Notably, lifestyle intervention has recently emerged as an important new research direction.
This study provides the first comprehensive bibliometric analysis and visualization of global research trends and hotspots in T2DOP, highlighting critical insights for clinical practice, including the identification of at-risk populations, biomarker-guided risk assessment, and therapeutic optimization, which complements existing clinical meta-analyses. Future research efforts should emphasize multidisciplinary collaboration and validation of the long-term efficacy of lifestyle interventions. For clinical practice, integrating bone density evaluation with biomarker screening (e.g., osteocalcin) in diabetic patients could enhance early fracture prevention. Public health initiatives should prioritize lifestyle interventions in high-risk populations (e.g., postmenopausal women) to mitigate the growing burden of diabetic osteoporosis.
2型糖尿病性骨质疏松症（T2DOP）因其骨质加速退化和骨折风险显著增加而受到广泛关注。与经典骨质疏松症不同，T2DOP患者常呈现出一种矛盾的模式：尽管骨微结构恶化，但在疾病早期他们的骨矿物质密度（BMD）正常甚至升高。这种矛盾凸显了将T2DOP识别为继发性骨质疏松症的一种独特且关键亚型的临床重要性。
我们对过去20年（2001年至2020年）发表的关于T2DOP的文献进行了文献计量分析，使用从Web of Science核心合集数据库检索到的数据。使用VOSviewer对文献计量网络进行可视化和分析。系统地研究了发表趋势、地理贡献、研究热点和关键词聚类。
在过去20年中，全球关于T2DOP的研究产出稳步增加，主要贡献来自北美、东亚和西欧。确定的研究热点包括风险预测、生物标志物（如晚期糖基化终产物）、并发症管理、特定人群特征（如绝经后女性）和治疗策略（如二甲双胍）。值得注意的是，生活方式干预最近已成为一个重要的新研究方向。
本研究首次对T2DOP的全球研究趋势和热点进行了全面的文献计量分析和可视化，突出了对临床实践的关键见解，包括高危人群的识别、生物标志物引导的风险评估和治疗优化，这补充了现有的临床荟萃分析。未来的研究应强调多学科合作以及生活方式干预长期疗效的验证。对于临床实践，将糖尿病患者的骨密度评估与生物标志物筛查（如骨钙素）相结合可以加强早期骨折预防。公共卫生举措应优先考虑对高危人群（如绝经后女性）进行生活方式干预，以减轻糖尿病性骨质疏松症日益加重的负担。
