Wu Nan, Ma Xinqian, Ni Wentao
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
Antibiotics (Basel). 2025 May 29;14(6):551. doi: 10.3390/antibiotics14060551.
has become a formidable pathogen in healthcare systems worldwide, primarily due to its remarkable capacity to develop multidrug resistance and cause life-threatening infections. While traditionally is considered an opportunistic pathogen of low virulence, accumulating evidence now underscores the emergence of hypervirulent (hvAB) strains. These strains combine heightened pathogenicity with extensive drug resistance, posing unprecedented challenges for clinical management and infection containment. This review comprehensively explores the molecular mechanisms driving hvAB's virulence and antimicrobial resistance and its evolutionary trajectory, clinical presentations, and global epidemiology. Additionally, we evaluate potential therapeutic strategies and their broader public health implications.
在全球医疗系统中已成为一种强大的病原体，主要是因为其具有显著的产生多重耐药性并引发危及生命感染的能力。虽然传统上被认为是一种低毒力的机会性病原体，但越来越多的证据现在强调了高毒力AB（hvAB）菌株的出现。这些菌株将增强的致病性与广泛的耐药性结合在一起，给临床管理和感染控制带来了前所未有的挑战。本综述全面探讨了驱动hvAB毒力和抗菌耐药性的分子机制及其进化轨迹、临床表现和全球流行病学。此外，我们评估了潜在的治疗策略及其更广泛的公共卫生影响。
