Bialvaei Abed Zahedi, Kouhsari Ebrahim, Salehi-Abargouei Amin, Amirmozafari Nour, Ramazanzadeh Rashid, Ghadimi-Daresajini Ali, Sedighi Mansour
a Department of Microbiology, Faculty of Medicine , Iran University of Medical Sciences , Tehran , Islamic Republic of Iran.
b Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences , Yazd , Islamic Republic of Iran.
J Chemother. 2017 Dec;29(6):327-337. doi: 10.1080/1120009X.2017.1338377. Epub 2017 Jun 16.
Acinetobacter baumannii is an important opportunistic pathogen that causes major public health concern especially in hospitalized patients due to the acquisition of multidrug resistance (MDR). The aim of this study was to systematically review published data about the prevalence rate of MDR-A. baumannii (MDR-AB) from different parts of Iran and provide an overall relative frequency (RF) using meta-analysis. All available national and international databanks were searched to find published studies up to June 2016. Quality of studies was assessed by STROB and PRISMA forms. Because of the significant heterogeneity observed, random effects model was used to combine the results. STATA SE version 11.2 was used for statistical analysis. Out of the 9646 results, 37 suitable articles were extracted according to inclusion and exlusion criteria. The pooled prevalence of MDR-AB was estimated 72% annually. Relative frequency of MDR-AB in different studies varied from 22.8 to 100%. Since the prevalence of MDR-AB is higher than many other countries, measures should be taken to keep the emergence and transmission of these strains to a minimum.
鲍曼不动杆菌是一种重要的机会致病菌，因其获得多重耐药性（MDR），尤其在住院患者中引起了重大的公共卫生问题。本研究的目的是系统回顾伊朗不同地区关于多重耐药鲍曼不动杆菌（MDR-AB）患病率的已发表数据，并通过荟萃分析提供总体相对频率（RF）。检索了所有可用的国家和国际数据库，以查找截至2016年6月发表的研究。采用STROB和PRISMA表格评估研究质量。由于观察到显著的异质性，使用随机效应模型合并结果。使用STATA SE 11.2版进行统计分析。在9646个结果中，根据纳入和排除标准提取了37篇合适的文章。估计MDR-AB的合并年患病率为72%。不同研究中MDR-AB的相对频率在22.8%至100%之间。由于MDR-AB的患病率高于许多其他国家，应采取措施将这些菌株的出现和传播降至最低。
