Trinchera Marilena, De Gaetano Silvia, Sole Elenoire, Midiri Angelina, Silvestro Serena, Mancuso Giuseppe, Catalano Teresa, Biondo Carmelo
Department of Human Pathology, University of Messina, 98125 Messina, Italy.
IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Antibiotics (Basel). 2025 Jun 14;14(6):606. doi: 10.3390/antibiotics14060606.
The accelerated spread of bacterial resistance has been demonstrated to reduce the effectiveness of antibiotic treatments for infections, resulting in higher morbidity and mortality rates, as well as increased costs for livestock producers. It is expected that the majority of future antimicrobial use will be in animal production. The management of antimicrobial resistance (AMR) in the livestock sector poses significant challenges due to the multifaceted nature of the problem. In order to identify appropriate solutions to the rise of antimicrobial resistance, it is imperative that we have a comprehensive understanding of the disease dynamics underpinning the ways in which antimicrobial resistance is transmitted between humans and animals. Furthermore, in consideration of the anticipated requirement to satisfy the global demand for food, it is imperative that we guarantee that resistance is not transmitted or propagated during the treatment and disposal of animal waste, particularly from intensive farming. It is also crucial to formulate a research agenda to investigate how antibiotic resistance in animal faeces from livestock farming is affected by intensified farming activities. The review analyses the environment's role in the transmission resistance chain and reviews methodologies for disrupting the link. A particular focus is placed on the limitations of the applied methodologies to reduce antimicrobial resistance in global animal production.
细菌耐药性的加速传播已被证明会降低抗生素治疗感染的效果，导致更高的发病率和死亡率，以及增加畜牧生产者的成本。预计未来大部分抗菌药物的使用将用于动物生产。由于问题的多面性，畜牧部门的抗菌药物耐药性（AMR）管理面临重大挑战。为了确定应对抗菌药物耐药性上升的适当解决方案，我们必须全面了解支撑抗菌药物耐药性在人类和动物之间传播方式的疾病动态。此外，考虑到满足全球粮食需求的预期要求，我们必须确保在处理和处置动物粪便（特别是来自集约化养殖的粪便）过程中不会传播或扩散耐药性。制定一项研究议程来调查集约化养殖活动如何影响畜牧养殖动物粪便中的抗生素耐药性也至关重要。该综述分析了环境在耐药性传播链中的作用，并回顾了破坏这种联系的方法。特别关注应用方法在全球动物生产中降低抗菌药物耐药性方面的局限性。
