Polymorphism in Glu-Phe-Asp Proteinoids.

Glu-Phe-Asp (GFD) proteinoids represent a class of synthetic polypeptides capable of self-assembling into microspheres, fibres, or combinations thereof, with morphology dramatically influencing their electrical properties. Extended recordings and detailed waveforms demonstrate that microspheres generate rapid, nerve-like spikes, while fibres exhibit consistent and gradual variations in voltage. Mixed networks integrate multiple components to achieve a balanced output. Electrochemical measurements show clear differences. Microspheres have a low capacitance of 1.926±5.735μF. They show high impedance at 6646.282±178.664 Ohm. Their resistance is low, measuring 15,830.739 ± 652.514 mΩ. This structure allows for quick ionic transport, leading to spiking behaviour. Fibres show high capacitance (9.912±0.171μF) and low impedance (209.400±0.286 Ohm). They also have high resistance (163,067.613 ± 9253.064 mΩ). This combination helps with charge storage and slow potential changes. The 50:50 mixture shows middle values for all parameters. This confirms that hybrid electrical properties have emerged. The differences come from basic structural changes. Microspheres trap ions in small, round spaces. This allows for quick release. In contrast, fibers spread ions along their length. This leads to slower wave propagation. In mixed systems, diverse voltage zones emerge, suggesting cooperative dynamics between morphologies. This electrical polymorphism in simple proteinoid systems may explain complexity in biological systems. This study shows that structural polymorphism in GFD proteinoids affects their electrical properties. This finding is significant for biomimetic computing and sheds light on prebiotic information-processing systems.