Wändell Per, Enarsson Malin, Feldreich Tobias, Lind Lars, Ärnlöv Johan, Carlsson Axel Carl
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Center for Primary Health Care Research, Lund University, SE-205 02 Malmö, Sweden.
Geriatrics (Basel). 2025 Jun 12;10(3):80. doi: 10.3390/geriatrics10030080.
Associations between high physical activity (PA) levels and incident atrial fibrillation (AF) is found in some earlier studies. We aim to study the association between levels of PA and AF in two cohorts.
We used data from the Uppsala Longitudinal Study of Adult Men (ULSAM) study, initiated in 1970, included men aged 50 years, with 2202 included in the study. Examinations were reiterated three times, with follow-up after in median 33 years, with 3.8-6.0% on the highest PA level. We also used data from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; with women 50%); mean age 70 years, baseline 2001-2004, median follow-up 15 years, with 961 included in the study, with 4.8% on the highest PA level. Cox regression analysis with hazard ratios (HRs) was used to study association between PA levels and incident AF, adjusted for CV risk factors: systolic blood pressure, LDL- and HDL-cholesterol, BMI, diabetes, and smoking.
Totally, in ULSAM 504 men during 59,958 person-years at risk, and in PIVUS 204 individuals during a follow-up of 11,293 person-years experienced an AF. Neither in ULSAM, PIVUS, nor in the meta-analysis of both cohorts, individuals with the highest PA level showed an increased AF risk, compared to individuals with lowest level of PA.
The benefits of PA in community dwelling individuals for its benefits to mental, metabolic, and cardiovascular health should guide public recommendations, rather than a possible risk of AF.
We studied the risk of incident atrial fibrillation at various levels of physical activity in two cohorts and found no statistically significant increased risk after adjusting for cardiovascular risk factors (systolic blood pressure, LDL- and HDL-cholesterol, BMI, diabetes, and smoking).
一些早期研究发现高体力活动（PA）水平与房颤（AF）发病之间存在关联。我们旨在研究两个队列中PA水平与AF之间的关联。
我们使用了始于1970年的乌普萨拉成年男性纵向研究（ULSAM）的数据，该研究纳入了50岁的男性，共有2202人参与。检查重复进行了三次，中位随访33年，最高PA水平组的比例为3.8 - 6.0%。我们还使用了乌普萨拉老年人血管前瞻性研究（PIVUS；纳入50%的女性）的数据；平均年龄70岁，基线时间为2001 - 2004年，中位随访15年，共有961人参与研究，最高PA水平组的比例为4.8%。采用带有风险比（HRs）的Cox回归分析来研究PA水平与房颤发病之间的关联，并对心血管危险因素进行了校正：收缩压、低密度脂蛋白和高密度脂蛋白胆固醇、体重指数、糖尿病和吸烟。
总体而言，在ULSAM中，504名男性在59958人年的风险期内发生房颤，在PIVUS中，204名个体在11293人年的随访期内发生房颤。无论是在ULSAM、PIVUS中，还是在两个队列的荟萃分析中，与PA水平最低的个体相比，PA水平最高的个体房颤风险均未增加。
PA对社区居住个体的精神、代谢和心血管健康有益，这一益处应指导公共建议，而非AF的潜在风险。
我们研究了两个队列中不同体力活动水平下房颤发病的风险，在校正心血管危险因素（收缩压、低密度脂蛋白和高密度脂蛋白胆固醇、体重指数、糖尿病和吸烟）后，未发现有统计学意义的风险增加。
