Bal Ismail, Macit Meltem, Alasiri Ali, Namli Onur Cem, Arshad Muhammad Sohail, Ahmad Zeeshan, Duman Gulengul, Kucuk Israfil
Institute of Nanotechnology, Gebze Technical University, Kocaeli 41400, Turkey.
Vocational School of Health Services, Istanbul Okan University, Istanbul 34959, Turkey.
Gels. 2025 Jun 11;11(6):448. doi: 10.3390/gels11060448.
In the present study, we developed a moxifloxacin (MXF)-encapsulated liposome-enriched alginate nanocomposite hydrogel coating. MXF was encapsulated in soy lecithin (SL:MXF:2:1) via the probe sonication method with an average efficiency of 80%. Two different manufacturing methods, including a micropipetting and a T-shaped microfluidic junction (TMJ) device technique, were used to incorporate the MXF-encapsulated liposomes into hydrogel matrices and layered as a coating on polymeric substrate material. Drug encapsulation and its incorporation into the hydrogel matrix significantly enhanced its stability and facilitated a prolonged drug release profile. A relatively rapid drug release was observed in the MXF-encapsulated liposome-loaded polymeric particulate layer developed via the micropipetting than the TMJ device technique. The findings confirmed sustained drug release behavior due to a hydrogel particulate structural uniformity conferred by the micromachine device, TMJ. Thus, these nanocomposite hydrogel coatings achieved can serve as a promising candidate for the treatment of ophthalmic or mucosal membrane infections.
在本研究中，我们开发了一种包载莫西沙星（MXF）的富含脂质体的海藻酸钠纳米复合水凝胶涂层。通过探头超声法将MXF包封于大豆卵磷脂（SL:MXF:2:1）中，平均包封效率为80%。采用两种不同的制备方法，包括微量移液法和T形微流控连接（TMJ）装置技术，将包载MXF的脂质体掺入水凝胶基质中，并作为涂层沉积在聚合物基材上。药物包封及其掺入水凝胶基质显著提高了其稳定性，并促进了药物的长效释放。通过微量移液法制备的载有包载MXF脂质体的聚合物颗粒层比TMJ装置技术观察到相对较快的药物释放。研究结果证实，由于微机械装置TMJ赋予水凝胶颗粒结构均匀性，从而实现了药物的持续释放。因此，所制备的这些纳米复合水凝胶涂层可作为治疗眼科或粘膜感染的有前景的候选材料。
