Valentino Anna, Yazdanpanah Sorur, Conte Raffaele, Calarco Anna, Peluso Gianfranco
Research Institute on Terrestrial Ecosystems (IRET)-CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
National Biodiversity Future Center (NBFC), 90133 Palermo, Italy.
Gels. 2024 Oct 24;10(11):689. doi: 10.3390/gels10110689.
Stimuli-responsive nanocomposite gels combine the unique properties of hydrogels with those of nanoparticles, thus avoiding the suboptimal results of single components and creating versatile, multi-functional platforms for therapeutic and diagnostic applications. These hybrid materials are engineered to respond to various internal and external stimuli, such as temperature, pH, light, magnetic fields, and enzymatic activity, allowing precise control over drug release, tissue regeneration, and biosensing. Their responsiveness to environmental cues permits personalized medicine approaches, providing dynamic control over therapeutic interventions and real-time diagnostic capabilities. This review explores recent advances in stimuli-responsive hybrid gels' synthesis and application, including drug delivery, tissue engineering, and diagnostics. Overall, these platforms have significant clinical potential, and future research is expected to lead to unique solutions to address unmet medical needs.
刺激响应性纳米复合凝胶结合了水凝胶和纳米颗粒的独特特性，从而避免了单一成分的次优结果，并为治疗和诊断应用创建了多功能的平台。这些混合材料经过设计，可对各种内部和外部刺激做出响应，如温度、pH值、光、磁场和酶活性，从而实现对药物释放、组织再生和生物传感的精确控制。它们对环境线索的响应性允许采用个性化医疗方法，对治疗干预措施进行动态控制并具备实时诊断能力。本文综述探讨了刺激响应性混合凝胶在合成与应用方面的最新进展，包括药物递送、组织工程和诊断。总体而言，这些平台具有巨大的临床潜力，预计未来的研究将带来独特的解决方案，以满足未满足的医疗需求。
