Kovačević Gordana, Vuković Vladimir, Nikolić Nataša, Bašica Branka, Radovanov Jelena, Čolović Popadić Aleksandra, Pejaković Budinski Milica, Dugandžija Tihomir, Golušin Zoran, Patić Aleksandra
Institute of Public Health of Vojvodina, 21000 Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Pathogens. 2025 Jun 3;14(6):558. doi: 10.3390/pathogens14060558.
Human papillomavirus (HPV) is one of the most common sexually transmitted infections, affecting both men and women. However, in Serbia, the previous epidemiological and clinical research on HPV has primarily focused on women due to its established role in cervical cancer, while the data on HPV prevalence in men remain scarce. This study analyzed 634 samples from men (mean age: 30 years, SD = 9.98; range: 18-79) from between 2012 and 2024. Overall, 30.76% of the tested men were HPV-positive, with the highest percentage of cases being observed in those aged 25-29 years (32.82%). The most common genotypes were HPV 16 and HPV 31 (22.05% each), followed by HPV6 (20.51%), HPV 56, and HPV 52 (9.23% each). The prevalence of HPV was the highest in the samples from men with genital warts (40.77%). Among the available vaccines, the nonavalent Gardasil 9 provides the broadest protection, covering genotypes found in 82% of the HPV-positive cases identified in this study. Our findings underscore the importance of comprehensive HPV prevention and control measures for the male population, contributing to ongoing research efforts aimed at reducing the burden of HPV-associated diseases in our region. Increasing the vaccination coverage among Serbian men could substantially reduce the overall burden of HPV-related diseases in both sexes.
人乳头瘤病毒（HPV）是最常见的性传播感染之一，影响男性和女性。然而，在塞尔维亚，先前关于HPV的流行病学和临床研究主要集中在女性身上，因为其在宫颈癌中已明确的作用，而男性中HPV流行率的数据仍然很少。本研究分析了2012年至2024年间来自男性的634份样本（平均年龄：30岁，标准差=9.98；范围：18 - 79岁）。总体而言，30.76%的受试男性HPV呈阳性，其中25 - 29岁的男性中观察到的病例百分比最高（32.82%）。最常见的基因型是HPV 16和HPV 31（各占22.05%），其次是HPV6（20.51%）、HPV 56和HPV 52（各占9.23%）。在患有尖锐湿疣的男性样本中，HPV流行率最高（40.77%）。在现有的疫苗中，九价加德西9提供了最广泛的保护，涵盖了本研究中82%的HPV阳性病例中发现的基因型。我们的研究结果强调了针对男性人群采取全面HPV预防和控制措施的重要性，有助于正在进行的旨在减轻我们地区HPV相关疾病负担的研究工作。提高塞尔维亚男性的疫苗接种覆盖率可以大幅减轻男女两性中HPV相关疾病的总体负担。
