Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats () Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones.

This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog-cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the upper and lower limbs, facial, dorsal, and appendicular thermal windows was assessed through infrared thermography. Additionally, heart rate, respiratory rate, and rectal temperature were recorded. Eighty male and female domestic cats were included in the study and randomly divided into four groups: CONTROL (placebo, 2 mL/cat orally), CBD (cannabidiol, 2 mg/kg orally), GABA (gabapentin, 100 mg/cat orally), and SFP (synthetic facial pheromone, two sprays/carrier). All cats underwent six experimental phases: T, T1st, T1st, T, T2nd, and T2nd. Drug administration was carried out at the end of T1st; the time between drug administration and T differed according to each drug's nature. Statistical differences were obtained between experimental groups and times in the average surface temperature of thermal windows and cardiorespiratory parameters. In particular, the CBD, GABA, and SFP groups exhibited differences during T2nd, in contrast to the control and T1st groups. In conclusion, the results suggest a pharmacological effect of CBD, GABA, and SFP on cats' physiological alterations in response to fear.