Paudel Pratikshya, Gharai Prabir Kumar
Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Department of Animal and Food Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
ACS Chem Neurosci. 2025 Jul 16;16(14):2561-2563. doi: 10.1021/acschemneuro.5c00367. Epub 2025 Jun 25.
Neurodegenerative diseases cause progressive neuronal loss, with current treatments offering only limited symptomatic relief. To overcome this, various strategies are being explored. One promising approach involves converting human mesenchymal stem cells (hMSCs) into functional neurons using a small molecule, alongside the use of fluorescent probes for real-time imaging. Therefore, developing a promising single compound that combines both differentiation-inducing and imaging capabilities without relying on growth factors could significantly advance neuroregenerative therapies and diagnostic strategies in neuroscience research.
神经退行性疾病会导致神经元逐渐丧失，目前的治疗方法只能提供有限的症状缓解。为了克服这一问题，人们正在探索各种策略。一种有前景的方法是使用小分子将人间充质干细胞（hMSCs）转化为功能性神经元，并使用荧光探针进行实时成像。因此，开发一种有前景的单一化合物，它兼具诱导分化和成像能力且不依赖生长因子，这可能会显著推动神经再生疗法以及神经科学研究中的诊断策略的发展。
