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肢体延长与重建手术的起源可追溯到1521年,当时历史上首次报道的干预手术是在圣依纳爵·罗耀拉身上进行的。

The origins of limb lengthening and reconstruction surgery date back to 1521 when the first intervention ever reported in history was performed on St. Ignatius of Loyola.

作者信息

Vandenbulcke Filippo, Lineham Beth, Malagoli Emiliano, Kirienko Alexander

机构信息

IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano - 20089, Milan, Italy.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele - 20072, Milan, Italy.

出版信息

Int Orthop. 2025 Sep;49(9):2289-2296. doi: 10.1007/s00264-025-06591-4. Epub 2025 Jun 25.

DOI:10.1007/s00264-025-06591-4
PMID:40560217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12405292/
Abstract

PURPOSE

To explore the historical case of Saint Ignatius of Loyola's leg injury and subsequent surgical interventions as a potential early instance of limb lengthening and reconstruction surgery.

METHODS

A detailed analysis of "A Pilgrim's Journey" (Ignatius of Loyola's autobiography) was conducted, focusing on orthopaedic descriptions of his injury and treatments.

RESULTS

In 1521, Íñigo López de Loyola sustained a severe, comminuted open fracture of the tibia due to a cannonball wound during the siege of Pamplona. Initial attempts at reduction were unsuccessful, leading to a non-union with significant deformity and shortening. He underwent a revision surgery, a procedure described as "carnage" and endured without a single lament. Although the fracture eventually united, residual shortening and a prominent bone deformity persisted. Unwilling to accept this disfigurement for social reasons, Ignatius requested a second, highly painful osteotomy to remove the protruding bone followed by continuous traction for "days and days of martyrdom" for progressive lengthening. Crucially, after these arduous treatments, Ignatius was able to walk and even ride a horse again. The only significant residual symptom was swelling in his leg by evening.

CONCLUSION

St. Ignatius of Loyola's case provides a compelling historical account of complex orthopaedic challenges in the early 16th century. The documented surgeries represent remarkably early attempts at managing non-union, deformity, and potentially achieving limb lengthening, predating modern reconstructive techniques by centuries. This historical narrative offers valuable insights into the nascent stages of orthopaedic surgery and highlights how a physical ordeal can profoundly shape one's life path.

摘要

目的

探讨圣依纳爵·罗耀拉腿部受伤及后续手术干预的历史案例,将其作为肢体延长和重建手术的一个潜在早期实例。

方法

对《朝圣之旅》(依纳爵·罗耀拉的自传)进行了详细分析,重点关注其中对他的伤势和治疗的骨科描述。

结果

1521年,伊尼戈·洛佩斯·德·罗耀拉在潘普洛纳围城战期间因炮弹伤导致胫骨严重粉碎性开放性骨折。最初的复位尝试未成功,导致骨折不愈合,并伴有明显畸形和缩短。他接受了一次翻修手术,该手术被描述为“大屠杀”,且他在手术过程中没有丝毫哀叹。尽管骨折最终愈合,但仍存在残余缩短和明显的骨畸形。由于社会原因,伊纳爵不愿接受这种毁容,于是请求进行第二次极其痛苦的截骨术,以切除突出的骨头,随后进行持续牵引,历经“数日的磨难”以逐渐延长肢体。至关重要的是,经过这些艰苦的治疗后,伊纳爵能够再次行走甚至骑马。唯一明显的残余症状是傍晚时腿部肿胀。

结论

圣依纳爵·罗耀拉的案例提供了一个关于16世纪早期复杂骨科挑战的引人注目的历史记录。所记录的手术代表了在处理骨折不愈合、畸形以及潜在实现肢体延长方面非常早期的尝试,比现代重建技术早了几个世纪。这一历史叙述为骨科手术的初期阶段提供了宝贵的见解,并凸显了身体磨难如何能深刻地塑造一个人的人生道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/88fe4b868cd2/264_2025_6591_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/3b212b1774db/264_2025_6591_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/73d4080c2248/264_2025_6591_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/dcf85fed589b/264_2025_6591_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/88fe4b868cd2/264_2025_6591_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/3b212b1774db/264_2025_6591_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/73d4080c2248/264_2025_6591_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/dcf85fed589b/264_2025_6591_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75a0/12405292/88fe4b868cd2/264_2025_6591_Fig4_HTML.jpg

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本文引用的文献

1
The Iron Man of the Renaissance: the contribution of Girolamo Fabrizi d'Acquapendente.文艺复兴时期的铁人:吉罗拉莫·法布里齐奥·达·阿克夸彭登特的贡献。
Int Orthop. 2020 Feb;44(2):399-402. doi: 10.1007/s00264-019-04449-0. Epub 2019 Nov 26.
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A Brief History of Limb Lengthening.肢体延长简史
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Medieval orthopaedic history in Germany: Hieronymus Brunschwig and Hans von Gersdorff.德国中世纪骨科史:希罗尼穆斯·布伦施维格与汉斯·冯·格尔斯多夫
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