Harkaway P S, Conlon P F, Hirsh J D, Allen W T
J Clin Pharmacol. 1985 Sep;25(6):444-7. doi: 10.1002/j.1552-4604.1985.tb02874.x.
The bioavailability profiles of two sustained-release oral theophylline preparations, Respbid and Theo-Dur, were compared in 19 adults with obstructive airways disease. Intravenous aminophylline was used as the reference standard. No significant differences were detected in fraction absorbed, peak-trough fluctuations, or time to peak concentrations.
在19名患有阻塞性气道疾病的成年人中比较了两种缓释口服茶碱制剂（Respbid和Theo-Dur）的生物利用度情况。静脉注射氨茶碱用作参考标准。在吸收分数、峰谷波动或达峰时间方面未检测到显著差异。
