Jock Janet, Beidelman Erika T, Phillips Meredith, Kobayashi Lindsay C, Chen Xiwei, Tollman Stephen, Kabudula Chodziwadziwa Whiteson, Bassil Darina T, Wagner Ryan, Berkman Lisa, Rosenberg Molly
Department of Political Science, Auburn University, Haley Center Auburn, Auburn, Alabama, United States of America.
Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana, United States of America.
PLoS One. 2025 Jun 25;20(6):e0326321. doi: 10.1371/journal.pone.0326321. eCollection 2025.
Alzheimer's disease and related dementias (ADRD) are a growing global health concern, with burdens projected to expand rapidly in the coming decades. Since cognitive decline typically precedes ADRD, it is crucial to identify interventions that may help slow cognitive decline and reduce ADRD risk. We used a quasi-experimental design, exploiting exogenous expansions of South Africa's Older Persons Grant for men, to estimate its impact on memory decline and ADRD risk in the rural Mpumalanga province of South Africa. We found that expanded pension eligibility was associated with slower memory decline for men who were eligible to receive the pension 5 years earlier [β = 0.027 SD, 95% CI = 0.023, 0.031], as well as for men who were eligible to receive the pension 1-4 years earlier [β = 0.009 SD, 95% CI = 0.004, 0.013]. We also found a 5.2 percentage point lower probability of dementia for men who were eligible for pension 5 years earlier [95% CI = -0.062, -0.032] and a 4.8 percentage point lower probability of dementia for men who became eligible to receive pension 1-4 years earlier [95% CI = -0.062, -0.032]. These findings demonstrate that beyond the policy intent of cash transfers to strengthen individual and household livelihoods, an important further benefit lies in promoting healthy cognitive aging in low- and middle- income countries.
阿尔茨海默病及相关痴呆症(ADRD)是一个日益引起全球健康关注的问题,预计在未来几十年负担将迅速扩大。由于认知能力下降通常先于ADRD出现,因此确定可能有助于减缓认知能力下降并降低ADRD风险的干预措施至关重要。我们采用了一种准实验设计,利用南非老年男性补助金的外部扩张,来估计其对南非姆普马兰加省农村地区记忆衰退和ADRD风险的影响。我们发现,养老金资格扩大与提前5年有资格领取养老金的男性记忆衰退减缓有关[β = 0.027标准差,95%置信区间 = 0.023,0.031],也与提前1 - 4年有资格领取养老金的男性有关[β = 0.009标准差,95%置信区间 = 0.004,0.013]。我们还发现,提前5年有资格领取养老金的男性患痴呆症的概率降低了5.2个百分点[95%置信区间 = -0.062,-0.032],提前1 - 4年有资格领取养老金的男性患痴呆症的概率降低了4.8个百分点[95%置信区间 = -0.062,-0.032]。这些发现表明,除了现金转移以加强个人和家庭生计的政策意图之外,一个重要的额外好处在于促进低收入和中等收入国家的健康认知老龄化。