Kato Maya, Nii Masafumi, Toriyabe Kuniaki, Tamaishi Yuya, Takakura Sho, Magawa Shoichi, Yasuma Taro, D'Alessandro-Gabazza Corina N, Fujimoto Hajime, Toda Masaaki, Cann Isaac, Kobayashi Tetsu, Gabazza Esteban C, Kondo Eiji, Ikeda Tomoaki
Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 514-8507, Japan.
Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan.
Antioxidants (Basel). 2025 May 31;14(6):670. doi: 10.3390/antiox14060670.
Preterm birth and low birth weight remain major contributors to neonatal morbidity and mortality, yet the underlying mechanisms are not fully understood. Maternal microbiota has been implicated in adverse pregnancy outcomes, but key mediators remain unidentified. We previously showed that the microbiota-derived peptide corisin induces epithelial apoptosis via mitochondrial membrane depolarization and reactive oxygen species accumulation. In this retrospective preliminary study, we evaluated the association between maternal serum corisin levels and pregnancy outcomes in 84 eligible women. Among them, 10 experienced preterm birth, and 22 delivered low-birth-weight infants. Corisin levels were significantly elevated in these groups compared with women with full-term, normal-weight deliveries. Preterm birth was associated with increased tissue factor, while low birth weight correlated with higher thrombin-antithrombin complex and soluble thrombomodulin and lower fibrinogen levels. Corisin concentrations showed negative correlations with maternal BMI, birth weight and length, and estimated fetal weight. Positive correlations were observed between corisin, myeloperoxidase, and several coagulation markers. These preliminary findings suggest that elevated maternal corisin levels are associated with adverse pregnancy outcomes and may reflect underlying mechanisms involving oxidative stress and coagulation activation. Further investigation is warranted to clarify its potential role as a microbiota-derived biomarker in pregnancy complications.
早产和低出生体重仍然是新生儿发病和死亡的主要原因，但其潜在机制尚未完全了解。母体微生物群与不良妊娠结局有关，但关键介质仍未确定。我们之前表明，微生物群衍生的肽corisin通过线粒体膜去极化和活性氧积累诱导上皮细胞凋亡。在这项回顾性初步研究中，我们评估了84名符合条件的女性的母体血清corisin水平与妊娠结局之间的关联。其中，10人早产，22人分娩低体重儿。与足月、正常体重分娩的女性相比，这些组中的corisin水平显著升高。早产与组织因子增加有关，而低出生体重与较高的凝血酶-抗凝血酶复合物和可溶性血栓调节蛋白以及较低的纤维蛋白原水平相关。Corisin浓度与母体BMI、出生体重和身长以及估计胎儿体重呈负相关。在corisin、髓过氧化物酶和几种凝血标志物之间观察到正相关。这些初步发现表明，母体corisin水平升高与不良妊娠结局有关，可能反映了涉及氧化应激和凝血激活的潜在机制。有必要进一步研究以阐明其作为微生物群衍生生物标志物在妊娠并发症中的潜在作用。
