Shoham Shani, Pintel Noam, Avni Dorit
Bio-Compounds and Immune-Mediated Diseases Group, MIGAL-Galilee Research Institute, 1101600 Kiryat Shemona, Israel.
Department of Biotechnology, Faculty of Science and Technology, Tel Hai College, 1220800 Kiryat Shemona, Israel.
Antioxidants (Basel). 2025 Jun 9;14(6):697. doi: 10.3390/antiox14060697.
Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, known for their potent antioxidant, anti-inflammatory, and prebiotic properties, show promise in alleviating oxidative damage and supporting beneficial gut bacteria. This review explores the multifaceted role of oxidative stress in IBD and highlights the therapeutic potential of microalgae-derived compounds. In addition, it examines the synergistic benefits of combining microalgal antioxidants with probiotics to promote gut homeostasis. Advances in delivery systems, including nanotechnology and symbiotic bacteria-microalgae interactions, are also discussed as emerging approaches for targeted treatment. The review concludes by identifying future research priorities focused on clinical translation and microalgae-based bioengineering innovations to enhance the efficacy and accessibility of therapeutics for IBD patients.
氧化应激是炎症性肠病（IBD）病理生理学的一个公认因素，会加剧慢性炎症和组织损伤。虽然传统的IBD疗法主要侧重于免疫调节，但针对氧化应激并促进肠道微生物健康的替代方法为缓解症状和疾病管理带来了新机遇。微藻以其强大的抗氧化、抗炎和益生元特性而闻名，在减轻氧化损伤和支持有益肠道细菌方面显示出前景。本综述探讨了氧化应激在IBD中的多方面作用，并强调了微藻衍生化合物的治疗潜力。此外，还研究了将微藻抗氧化剂与益生菌联合使用以促进肠道稳态的协同益处。包括纳米技术和共生细菌 - 微藻相互作用在内的递送系统进展也作为靶向治疗的新兴方法进行了讨论。综述最后确定了未来的研究重点，集中在临床转化和基于微藻的生物工程创新，以提高IBD患者治疗的疗效和可及性。
