Gilbert R D, Lis L, Longo L D
J Dev Physiol. 1985 Oct;7(5):299-304.
In an effort to understand the effects of temperature changes on fetal oxygenation, the temperature effects were measured on oxygen affinity of whole blood from term human fetuses. The blood obtained was tonometered at delivery in two flasks gassed with 95% N2 (+ 5% CO2 or 20.9% + 5% CO2, and mixed aliquots from each flask in different proportions to obtain samples for analysis of PO2 and percent saturation. The oxyhaemoglobin dissociation curve was constructed and P50 determined at two or three different temperatures for each batch of blood. As temperature increased from 30 to 41 degrees C, human fetal blood bound O2 less avidly, the temperature coefficient for changes in P50 being 0.0255 per degree C. This temperature effect was similar to that in adult blood, although at any temperature O2 affinity of fetal blood was greater than that of the adult. Placental oxygen exchange could be significantly affected by changes in temperature such as occur during hypo- or hyperthermia, as with maternal exercise.
为了了解温度变化对胎儿氧合的影响，对足月胎儿全血的氧亲和力进行了温度效应测量。所采集的血液在分娩时于两个烧瓶中用95%氮气（+5%二氧化碳或20.9%+5%二氧化碳）进行血气分析，然后将每个烧瓶中的混合等分试样按不同比例混合，以获得用于分析氧分压（PO2）和饱和度百分比的样本。构建氧合血红蛋白解离曲线，并针对每批血液在两到三个不同温度下测定P50。当温度从30摄氏度升高到41摄氏度时，人类胎儿血液与氧气的结合能力减弱，P50变化的温度系数为每摄氏度0.0255。这种温度效应与成人血液中的相似，尽管在任何温度下胎儿血液的氧亲和力都高于成人。温度变化（如体温过低或过高时发生的变化，如母体运动时）可能会显著影响胎盘的氧交换。
