Wilkening R B, Battaglia F C, Meschia G
J Dev Physiol. 1985 Oct;7(5):313-9.
In 30 experiments performed on 5 pregnant sheep, the rate of glucose transfer from the placenta to fetus via the umbilical circulation was measured while varying uterine blood flow by means of a cuff-type occluder and while maintaining a constant maternal glucose concentration by means of a 'glucose clamp'. Over the range of uterine blood flows obtained, there was no significant effect on the simultaneously measured umbilical blood flow. Fetal glucose uptake and arterial glucose concentration remained normal as the uterine blood flow rate decreased from 600 to 300 ml per min per kg of fetus. At blood flow rates less than 300 ml.min-1.kg-1, the fetal glucose uptake decreased and became negative in one instance while the arterial glucose concentration became variable and markedly increased in 2 animals. This increase in fetal glucose concentration was associated with a decrease in the uterine oxygen delivery rate, a decrease in fetal oxygen content and a decrease in fetal oxygen uptake. These observations support the concept that fetal glucose metabolism is altered by severe hypoxia and demonstrate that there is little effect of uterine blood flow on fetal glucose uptake in the normal physiological range.
在对5只怀孕绵羊进行的30项实验中，通过袖带式阻塞器改变子宫血流量，并通过“葡萄糖钳夹”维持母体葡萄糖浓度恒定，同时测量葡萄糖经脐循环从胎盘向胎儿的转运速率。在所获得的子宫血流量范围内，对同时测量的脐血流量没有显著影响。当子宫血流速率从每分钟每千克胎儿600毫升降至300毫升时，胎儿葡萄糖摄取和动脉葡萄糖浓度保持正常。在血流速率低于每分钟每千克300毫升时，胎儿葡萄糖摄取减少，有一例变为负值，而在2只动物中，动脉葡萄糖浓度变得不稳定且显著升高。胎儿葡萄糖浓度的这种升高与子宫氧输送速率降低、胎儿氧含量降低和胎儿氧摄取减少有关。这些观察结果支持了严重缺氧会改变胎儿葡萄糖代谢的观点，并表明在正常生理范围内子宫血流量对胎儿葡萄糖摄取几乎没有影响。
