Boer G J, Hall K, Sara V R
J Dev Physiol. 1985 Oct;7(5):321-7.
Somatomedin serum levels of congenitally vasopressin-deficient Brattleboro rats were determined postnatally between day 1 and 55, and compared with heterozygous control values. Assays were performed with a radioimmunoassay of insulin-like growth factor 1 (IGF-1). A transient enhancement of immunoreactive IGF-1 levels between day 8 and 21 of age and a reduction in adulthood was found. This observation shows that the early growth impairments of the Brattleboro mutant are not due to a deficiency of IGF-1.
测定了先天性血管加压素缺乏的布拉特洛伯勒大鼠出生后1至55天的生长调节素血清水平，并与杂合子对照值进行比较。采用胰岛素样生长因子1（IGF-1）放射免疫分析法进行检测。结果发现，在8至21日龄之间免疫反应性IGF-1水平出现短暂升高，成年后则降低。这一观察结果表明，布拉特洛伯勒突变体的早期生长障碍并非由于IGF-1缺乏所致。
