Tsao Ching-Han, Hsieh Wei-Chen, Lin Feng-Jen, Liu Fu-Tong, Yang Ri-Yao
Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
AHMC Dermatology and Research Center, Arcadia, CA 91007, USA.
Biomolecules. 2025 Jun 8;15(6):837. doi: 10.3390/biom15060837.
Galectin-12, a member of the galectin family of glycan-binding proteins, exhibits restricted tissue distribution, primarily in adipocytes and sebocytes. In sebocytes, it modulates the cell cycle, influences lipid metabolism through interactions with peroxisome proliferator-activated receptor γ (PPARγ), and exerts immunomodulatory functions by activating immune signaling pathways. Dysregulation of sebocyte homeostasis, lipid metabolism, and immune responses contributes to the pathogenesis of a number of skin diseases, underscoring the therapeutic potential of targeting galectin-12. The review summarizes and discusses current developments in the field to foster future research in this important but underexplored galectin.
半乳糖凝集素-12是聚糖结合蛋白半乳糖凝集素家族的成员之一，其组织分布有限，主要存在于脂肪细胞和皮脂腺细胞中。在皮脂腺细胞中，它调节细胞周期，通过与过氧化物酶体增殖物激活受体γ（PPARγ）相互作用影响脂质代谢，并通过激活免疫信号通路发挥免疫调节功能。皮脂腺细胞稳态、脂质代谢和免疫反应的失调促成了多种皮肤病的发病机制，这突出了靶向半乳糖凝集素-12的治疗潜力。本综述总结并讨论了该领域的当前进展，以促进对这种重要但研究不足的半乳糖凝集素的未来研究。
