Seiringer Peter, Hillig Christina, Schäbitz Alexander, Jargosch Manja, Pilz Anna Caroline, Eyerich Stefanie, Szegedi Andrea, Sochorová Michaela, Gruber Florian, Zouboulis Christos C, Biedermann Tilo, Menden Michael P, Eyerich Kilian, Törőcsik Daniel
Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.
Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Front Immunol. 2024 Feb 16;15:1334844. doi: 10.3389/fimmu.2024.1334844. eCollection 2024.
Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on their potential contribution to disease development, we investigated the spatial transcriptome of sebaceous glands in psoriasis and atopic dermatitis patients across lesional and non-lesional human skin samples. Both atopic dermatitis and psoriasis sebaceous glands expressed genes encoding key proteins for lipid metabolism and transport such as , and Also, inflammation-related was identified as a common spatially variable gene. In atopic dermatitis, genes mainly related to lipid metabolism (e.g. , or as well as disease-specific genes, i.e., Th2 inflammation-related lipid-regulating were differentially expressed. On the contrary, in psoriasis, more inflammation-related spatially variable genes (e.g. , , ) were identified. Other psoriasis-specific enriched pathways included lipid metabolism (e.g. , keratinization (e.g. ), neutrophil degranulation, and antimicrobial peptides (e.g. ). In conclusion, our results show that sebaceous glands contribute to skin homeostasis with a cell type-specific lipid metabolism, which is influenced by the inflammatory microenvironment. These findings further support that sebaceous glands are not bystanders in inflammatory skin diseases, but can actively and differentially modulate inflammation in a disease-specific manner.
皮脂腺会引发痤疮，然而，它们在其他炎症性皮肤病中的作用仍不清楚。为了阐明它们对疾病发展的潜在贡献，我们研究了银屑病和特应性皮炎患者病变和非病变人体皮肤样本中皮脂腺的空间转录组。特应性皮炎和银屑病的皮脂腺均表达编码脂质代谢和转运关键蛋白的基因，如 、 ，以及 。此外，炎症相关的 被鉴定为一个常见的空间可变基因。在特应性皮炎中，主要与脂质代谢相关的基因（如 、 或 ）以及疾病特异性基因，即与Th2炎症相关的脂质调节基因 存在差异表达。相反，在银屑病中，鉴定出更多炎症相关的空间可变基因（如 、 、 ）。其他银屑病特异性富集途径包括脂质代谢（如 ）、角质化（如 ）、中性粒细胞脱颗粒和抗菌肽（如 ）。总之，我们的结果表明，皮脂腺通过细胞类型特异性脂质代谢对皮肤稳态做出贡献，这种代谢受炎症微环境影响。这些发现进一步支持皮脂腺在炎症性皮肤病中并非旁观者，而是可以以疾病特异性方式积极且有差异地调节炎症。
