Zhu Chenyu, Ding Xiaoqing, Chen Min, Feng Jie, Zou Jun, Zhang Lingli
School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
School of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China.
Biomolecules. 2025 Jun 18;15(6):893. doi: 10.3390/biom15060893.
Skeletal muscles and bones maintain musculoskeletal system function through their collaborative interaction, whereby muscles regulate bone metabolism via mechanical coupling. An increasing number of studies have shown that various cytokines secreted by skeletal muscles during exercise closely regulate the balance of bone homeostasis. Interleukin-6 (IL-6), one of the first muscle-secreted factors to be discovered, not only plays an important role in regulating the function of the muscle itself but also regulates bone metabolic processes in a bidirectional manner through multiple complex signal transduction pathways, thereby affecting the balance between bone formation and bone resorption. The exact mechanism by which IL-6 regulates bone metabolism is not fully understood, and there are few summaries on how exercise affects bone metabolism through IL-6 from skeletal muscles. Accordingly, this study will take skeletal muscle-derived IL-6 as an entry point to explore how the cross-organ regulatory activities of the muscles targeting bones during exercise affect bone metabolic processes. This study also aims to improve the mechanism of muscle-bone crosstalk under the effect of exercise and provide a theoretical basis and clinical diagnosis and treatment ideas from multiple perspectives for exercise to improve bone health.
骨骼肌和骨骼通过协同相互作用维持肌肉骨骼系统功能，其中肌肉通过机械耦合调节骨代谢。越来越多的研究表明，运动过程中骨骼肌分泌的各种细胞因子密切调节骨稳态平衡。白细胞介素-6（IL-6）是最早发现的肌肉分泌因子之一，不仅在调节肌肉自身功能中起重要作用，还通过多种复杂信号转导途径双向调节骨代谢过程，从而影响骨形成与骨吸收之间的平衡。IL-6调节骨代谢的确切机制尚未完全明确，且关于运动如何通过骨骼肌来源的IL-6影响骨代谢的总结较少。因此，本研究将以骨骼肌来源的IL-6为切入点，探讨运动过程中肌肉对骨骼的跨器官调节活动如何影响骨代谢过程。本研究还旨在完善运动作用下肌肉与骨骼相互作用的机制，从多个角度为运动改善骨骼健康提供理论依据以及临床诊断和治疗思路。
