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裸盖菇素在创伤性脑损伤恢复中的潜在作用：一项叙述性综述。

The Potential Role of Psilocybin in Traumatic Brain Injury Recovery: A Narrative Review.

作者信息

Palmer Charles, Ferber Ally T, Greenwald Brian D

机构信息

Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA.

Department of Physical Medicine and Rehabilitation, JFK Johnson Rehabilitation Institute at Hackensack Meridian Health, Edison, NJ 08820, USA.

出版信息

Brain Sci. 2025 May 26;15(6):572. doi: 10.3390/brainsci15060572.

DOI:10.3390/brainsci15060572
PMID:40563744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12190232/
Abstract

This narrative review explores psilocybin's potential use as a therapeutic agent in patients with traumatic brain injury (TBI). We engaged in a search of PubMed, ScienceDirect, and Cochrane's databases for information on the effects of psilocybin. We also reviewed articles where psilocybin was used in patients with TBI. Articles from 2000-2025 were included. A total of 29 articles met our initial inclusion criteria. Additionally, 13 articles were obtained from reference lists and 3 more articles on the legality of psilocybin from public websites. Assisted psilocybin use may have benefits in TBI by reducing inflammation, promoting neuroplasticity and neuroregeneration, and alleviating associated mood disorders. Positive findings in related fields, like treatment for depression and addiction, highlight the necessity for more extensive clinical trials on psilocybin's role in TBI recovery.

摘要

本叙述性综述探讨了裸盖菇素在创伤性脑损伤（TBI）患者中作为治疗药物的潜在用途。我们在PubMed、ScienceDirect和Cochrane数据库中搜索了有关裸盖菇素作用的信息。我们还查阅了使用裸盖菇素治疗TBI患者的文章。纳入了2000年至2025年的文章。共有29篇文章符合我们的初始纳入标准。此外，从参考文献列表中获取了13篇文章，并从公共网站上获取了另外3篇关于裸盖菇素合法性的文章。辅助使用裸盖菇素可能通过减轻炎症、促进神经可塑性和神经再生以及缓解相关情绪障碍而对TBI有益。相关领域（如抑郁症和成瘾治疗）的积极研究结果凸显了对裸盖菇素在TBI恢复中作用进行更广泛临床试验的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/10a57b2fbeb7/brainsci-15-00572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/a6a4cb313fd0/brainsci-15-00572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/4d22a92996cb/brainsci-15-00572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/c00598cb87d7/brainsci-15-00572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/10a57b2fbeb7/brainsci-15-00572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/a6a4cb313fd0/brainsci-15-00572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/4d22a92996cb/brainsci-15-00572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/c00598cb87d7/brainsci-15-00572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896c/12190232/10a57b2fbeb7/brainsci-15-00572-g004.jpg

相似文献

[1]
The Potential Role of Psilocybin in Traumatic Brain Injury Recovery: A Narrative Review.

Brain Sci. 2025-5-26

[2]
Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injury.

Cochrane Database Syst Rev. 2016-7-1

[3]
Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans.

Neurosci Biobehav Rev. 2025-8

[4]
The educational effects of portfolios on undergraduate student learning: a Best Evidence Medical Education (BEME) systematic review. BEME Guide No. 11.

Med Teach. 2009-4

[5]
Psilocybin's Potential Mechanisms in the Treatment of Depression: A Systematic Review.

J Psychoactive Drugs. 2024

[6]
Fitness training for cardiorespiratory conditioning after traumatic brain injury.

Cochrane Database Syst Rev. 2017-12-29

[7]
Music interventions for improving psychological and physical outcomes in people with cancer.

Cochrane Database Syst Rev. 2021-10-12

[8]
Unconditional cash transfers for reducing poverty and vulnerabilities: effect on use of health services and health outcomes in low- and middle-income countries.

Cochrane Database Syst Rev. 2022-3-29

[9]
Pharmacological interventions for people with borderline personality disorder.

Cochrane Database Syst Rev. 2022-11-14

[10]
Psychological therapies for post-traumatic stress disorder and comorbid substance use disorder.

Cochrane Database Syst Rev. 2016-4-4

本文引用的文献

[1]
De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli.

Microb Biotechnol. 2025-4

[2]
Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis.

Clin Pharmacokinet. 2025-1

[3]
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases.

Pharmacol Rep. 2024-12

[4]
Psilocybin reduces functional correlation and the encoding of spatial information by neurons in mouse retrosplenial cortex.

Eur J Neurosci. 2024-11

[5]
Do classic psychedelics increase the risk of seizures? A scoping review.

Eur Neuropsychopharmacol. 2024-8

[6]
Acute Adverse Effects of Therapeutic Doses of Psilocybin: A Systematic Review and Meta-Analysis.

JAMA Netw Open. 2024-4-1

[7]
Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential.

Mol Psychiatry. 2024-3

[8]
Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue.

Life (Basel). 2023-12-15

[9]
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study.

Brain Behav Immun. 2023-11

[10]
Psilocybin history, action and reaction: A narrative clinical review.

J Psychopharmacol. 2023-9

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