Rong Xuhui, Gao Guoliang, Lou Jiang, Wang Xiaolei, Han Wenjia
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, China; Shandong Institute of Endocrine & Metabolic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, China; Jinan Key Laboratory of Translational Medicine on Metabolic Diseases, 18877 Jingshi Road, Jinan, China; Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, Shandong, China.
Carbohydr Polym. 2025 Apr 1;353:123257. doi: 10.1016/j.carbpol.2025.123257. Epub 2025 Jan 20.
Chronic infected wounds present a prolonged and challenging healing process due to physiological imbalances, making them susceptible to secondary injuries from external mechanical contact. Conventional wound dressings lack antibacterial, strong adhesive, and on-demand detachable properties, resulting in suboptimal outcomes in treating such wounds. Here, we introduce a dual-network hydrogel consisting of SBMA (sulfobetaine methacrylate) and polyacrylamide, synthesized through a two-step thermal/light polymerization process. This hydrogel incorporates cationic modified bacterial cellulose (QBC) and quercetin to promote antibacterial and cell migration properties, designed specifically for treating full-thickness wounds infected with Staphylococcus aureus. On the 15th day of the infected wound healing experiment, the wound healing rate reached 98.9 %. SBMA within the system can enhance adhesion and provide bacterial resistance. QBC intercalated within the system ensures the stability of the gel structure and strengthens bacterial resistance. Quercetin can modulate inflammatory responses and promote fibroblast proliferation. Thus, this study introduces a multifunctional biomaterial for managing chronic infected wounds, holding promise as a next-generation dressing in wound care.
由于生理失衡，慢性感染伤口呈现出漫长且具有挑战性的愈合过程，使其容易受到外部机械接触造成的二次损伤。传统伤口敷料缺乏抗菌、强粘附和按需可拆卸的特性，导致在治疗此类伤口时效果欠佳。在此，我们介绍一种由甲基丙烯酰氧乙基磺酸甜菜碱（SBMA）和聚丙烯酰胺组成的双网络水凝胶，它通过两步热/光聚合过程合成。这种水凝胶包含阳离子改性细菌纤维素（QBC）和槲皮素，以促进抗菌和细胞迁移特性，专为治疗金黄色葡萄球菌感染的全层伤口而设计。在感染伤口愈合实验的第15天，伤口愈合率达到98.9%。系统中的SBMA可增强粘附力并提供抗菌性。插入系统中的QBC确保凝胶结构的稳定性并增强抗菌性。槲皮素可调节炎症反应并促进成纤维细胞增殖。因此，本研究介绍了一种用于管理慢性感染伤口的多功能生物材料，有望成为伤口护理中的下一代敷料。
