Huang Kang, Mi Bobin, Xiong Yuan, Fu Zicai, Zhou Wenyun, Liu Wanjun, Liu Guohui, Dai Guandong
Department of Orthopedics, Southern Medical University Pingshan Hospital, No. 19 Renmin Street, Pingshan District, Shenzhen City, Guangdong Province, 518118, P.R. China.
Department of Orthopedics, Pingshan District Peoples'Hospital of Shenzhen, No. 19 Renmin Street, Pingshan District, Shenzhen City, Guangdong Province, 518118, P.R. China.
Burns Trauma. 2025 Feb 7;13:tkae052. doi: 10.1093/burnst/tkae052. eCollection 2025.
Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the wound repair process in diabetic patients, significantly impeding diabetic wound healing; therefore, angiogenesis and its role in diabetic wound repair have emerged as important areas of research. This review aims to delve into the mechanisms of angiogenesis, the effects of diabetes on angiogenesis, and the association between angiogenesis and diabetic wound repair. This will ultimately offer valuable guidance regarding the ideal timing of diabetic wound treatment in a clinical setting.
糖尿病是一种普遍存在的慢性代谢紊乱疾病，常伴有伤口愈合受损等并发症。多种因素，最显著的是血管缺陷，控制着糖尿病患者的伤口修复过程，严重阻碍糖尿病伤口愈合；因此，血管生成及其在糖尿病伤口修复中的作用已成为重要的研究领域。本综述旨在深入探讨血管生成的机制、糖尿病对血管生成的影响以及血管生成与糖尿病伤口修复之间的关联。这最终将为临床环境中糖尿病伤口治疗的理想时机提供有价值的指导。
