Dokuchaeva Anna A, Podolskaya Kseniya S, Zhuravleva Irina Yu
Institute of Experimental Biology and Medicine, «E.Meshalkin National Medical Research Center» of the Ministry of Health of the Russian Federation («E.Meshalkin NMRC»), 15, Rechkunovskaya str., Novosibirsk 630055, Russia.
Biomedicines. 2025 Jun 5;13(6):1385. doi: 10.3390/biomedicines13061385.
Ultrasound Doppler diagnostics is a modern diagnostic method, routinely used to determine the blood flow velocity in vessels in clinical practice and scientific experiments. The aim of this study was to investigate hemodynamics and identify blood flow velocity norms for various age groups of animals in the range of two to six months. This study presents the blood flow velocity characteristics in different areas of the abdominal aorta of 30 growing Wistar rats two to six months old. The data from senile rats aged 24 months were used as a reference, since these animals should not show any changes in hemodynamics associated with the active growth of the organism. Ultrasound screening in the group of growing rats was performed monthly, and blood flow velocity was measured at three points: proximal to the renal arteries, distal to the renal arteries, and before the bifurcation zone of the abdominal aorta. The obtained data can be used as normative values in in vivo small-diameter tissue-engineered vascular graft (TEVG) studies to assess changes in hemodynamics.
超声多普勒诊断是一种现代诊断方法，在临床实践和科学实验中常规用于测定血管中的血流速度。本研究的目的是调查血流动力学，并确定2至6个月龄动物各年龄组的血流速度标准。本研究呈现了30只2至6个月龄生长中的Wistar大鼠腹主动脉不同区域的血流速度特征。将24月龄老年大鼠的数据用作参考，因为这些动物不应出现与机体活跃生长相关的血流动力学变化。对生长中大鼠组每月进行超声筛查，并在三个点测量血流速度：肾动脉近端、肾动脉远端以及腹主动脉分叉区之前。所获得的数据可作为体内小直径组织工程血管移植物（TEVG）研究中的标准值，以评估血流动力学变化。
