Barton B E, Levy D A
J Immunopharmacol. 1985;7(3):373-83. doi: 10.3109/08923978509026482.
A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conjugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the possibility that the drug could act as a contact sensitizing agent like DNCB. It was found that Amoscanate could induce a delayed-type hypersensitivity (DTH) response when painted on the shaved skin of guinea pigs. Moreover, the type of DTH response elicited was found to be cutaneous basophilic hypersensitivity (CBH). The significance of these findings are discussed.
强效抗血吸虫药硝硫氰胺，当以药物 - 蛋白质缀合物的形式经口给药或肠胃外给药时，被发现能诱导强烈的血清抗体反应。由于初步证据表明该药物可在体内与蛋白质共价结合，我们决定研究该药物是否能像二硝基氯苯一样作为接触致敏剂。结果发现，将硝硫氰胺涂抹在豚鼠剃毛的皮肤上时，它能诱导迟发型超敏反应（DTH）。此外，所引发的DTH反应类型被发现是皮肤嗜碱性超敏反应（CBH）。本文讨论了这些发现的意义。
