在植入马链球菌的悉生小鼠中氨甲酰苯胺转化为致突变代谢物。
Conversion of amoscanate to a mutagenic metabolite in gnotobiotic mice implanted with Streptococcus equinus.
作者信息
Reddy B S, Batzinger R P, Molineaux C J, Bueding E
出版信息
Antimicrob Agents Chemother. 1982 Oct;22(4):707-8. doi: 10.1128/AAC.22.4.707.
Abstract
Recent in vitro studies indicate that intestinal bacteria convert amoscanate (4-nitro-4'-isothiocyanodiphenylamine), an antischistosomal drug, to a potent mutagen. The present study indicates that the implantation of germfree mice with Streptococcus equinus, isolated from the small intestine of conventional mice, restores the mutagenic activation of amoscanate in vivo.
摘要
最近的体外研究表明，肠道细菌可将抗血吸虫药物硝硫氰胺（4-硝基-4'-异硫氰基二苯胺）转化为一种强诱变剂。本研究表明，将从常规小鼠小肠分离出的马链球菌植入无菌小鼠体内，可恢复硝硫氰胺在体内的诱变活性。
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本文引用的文献
1
Protection by antibiotics against experimental focal cholangitis produced in mice by a schistosomicidal isothiocyanate.抗生素对由一种杀血吸虫异硫氰酸酯在小鼠体内引发的实验性局灶性胆管炎的保护作用。
Hepatology. 1981 Jan-Feb;1(1):21-7. doi: 10.1002/hep.1840010104.
2
Recognition of group D streptococcal species of human origin by biochemical and physiological tests.通过生化和生理学测试识别源自人类的D组链球菌菌种。
Appl Microbiol. 1972 Jun;23(6):1131-9. doi: 10.1128/am.23.6.1131-1139.1972.
3
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.用沙门氏菌/哺乳动物微粒体诱变性试验检测致癌物和诱变剂的方法。
Mutat Res. 1975 Dec;31(6):347-64. doi: 10.1016/0165-1161(75)90046-1.
4
5
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6
Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats.在无菌大鼠中用偶氮甲烷和二甲基肼诱导结肠癌发生
Cancer Res. 1975 Feb;35(2):287-90.
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